{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:40:45Z","timestamp":1783107645297,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:00:00Z","timestamp":1461888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scleroderma with characteristics of other connective tissue diseases is called scleroderma overlap syndrome (<jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content>); the clinical features of which have yet to be investigated among Thai patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the clinical differences between pure scleroderma and <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A historical cohort study was conducted among patients with pure scleroderma versus those with <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content>. Subjects were over 18 years of age and followed up at Srinagarind Hospital, Khon Kaen University, Thailand, between January 2006 and December 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and three medical records were included (276 female <jats:italic>vs<\/jats:italic>. 127 male). <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content> was found in 68 cases (16.9%): (i) scleroderma\u2013polymyositis overlap (<jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>), the most common type of <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content> (48 cases; 70.6%); (ii) scleroderma\u2013systemic lupus erythematosus overlap (11 cases; 16.2%); and (iii) scleroderma\u2013rheumatoid arthritis overlap (nine cases; 13.2%). Mean age at onset of non\u2010systemic sclerosis symptoms was 46.9 \u00b1 11.8 years (range, 19.8\u201374.3). Characteristically, sufferers of <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content> as against pure scleroderma were younger, had less frequent anti\u2010topoisomerase I (<jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content>) and needed moderate\u2010 to high\u2010dose steroid and immunosuppressant therapy during follow\u2010up. <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> presented the clinical features of scleroderma at onset and during follow\u2010up looks like pure scleroderma having vasculopathy, severity of skin tightness, and gastrointestinal, cardiopulmonary and renal involvement. Anti\u2010Ro52 was the most common serology among sufferers of <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content> (31.6%). <jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content> was associated with pure scleroderma patients (<jats:italic>P<\/jats:italic> = 0.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content> rather than pure scleroderma presented in younger Thai scleroderma patients and <jats:styled-content style=\"fixed-case\">SOV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> was the most common subtype and its clinical features were similar to those of pure scleroderma. <jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content> was strongly associated with the 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