{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:49:54Z","timestamp":1790650194276,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002462","name":"Chungnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>There is growing evidence that cold\u2010inducible <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010binding protein (<jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content>) promotes inflammatory responses. This study investigated the relationship between <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> and rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood and synovial fluid were collected from 15 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and from 16 patients with osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>). The concentration of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> was measured with the sandwich enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of serum <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> was significantly elevated in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patient group (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients = 26.39 \u00b1 10.48 pg\/mL, <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> patients = 17.14 \u00b1 7.24 pg\/mL, <jats:italic>P<\/jats:italic> = 0.009). Furthermore, the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patient group had a significantly higher <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> concentration than that of the <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> patient group in synovial fluid (153.56 \u00b1 108.93 pg\/mL <jats:italic>vs<\/jats:italic>. 23.63 \u00b1 16.18 pg\/mL, <jats:italic>P<\/jats:italic> &lt; 0.001). The mean synovial fluid concentration of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> was significantly higher than that of the serum concentration in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patient group (serum concentration = 26.39 \u00b1 10.48 pg\/mL, synovial fluid = 153.56 \u00b1 108.93 pg\/mL, <jats:italic>P<\/jats:italic> &lt; 0.001). Disease Activity Score of 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28)\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> (erythrocyte sedimentation rate) and <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (C\u2010reactive protein) were positively correlated with the synovial fluid concentration of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>:<jats:italic> r<\/jats:italic> = 0.582, <jats:italic>P<\/jats:italic> = 0.023; <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>:<jats:italic> r<\/jats:italic> = 0.541, <jats:italic>P<\/jats:italic> = 0.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The serum and synovial concentrations of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients were increased compared to the <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> patients. Additionally, the synovial concentration of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients correlated well with disease activity, that is, the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. Based on these results, <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> mediates inflammation and is a potential marker for synovial inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12892","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T15:53:06Z","timestamp":1466178786000},"page":"148-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Serum and synovial fluid concentrations of cold\u2010inducible <scp>RNA<\/scp>\u2010binding protein in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"21","author":[{"given":"In Seol","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Keol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Cheol","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20159"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15640-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3368"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00530-1"},{"key":"e_1_2_7_7_1","first-page":"289","article-title":"Decreased expression of cold\u2010inducible RNA\u2010binding protein (CIRP) in male germ cells at elevated temperature","volume":"152","author":"Nishiyama H","year":"1998","journal-title":"Am J 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