{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:52:30Z","timestamp":1790855550096,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the diagnostic values of presepsin and procalcitonin in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) by identifying those with bacterial infection<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>During June 2014\u2013September 2015, 126 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and 25 healthy controls were enrolled. <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients were divided into an infection group and a non\u2010infection group. Infection was diagnosed by clinical symptoms, microbiological or radiographic methods, and good response to antibiotics. Concentrations of plasma presepsin, serum procalcitonin, C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), and white blood cell counts (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) were measured and compared in each group. The correlations with the Sequential Organ Failure Assessment (<jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content>) Score and these markers were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients included 26 patients in the infection group, 45 patients in the <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\u2010positive non\u2010infection group (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> &gt; 0.3 mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>), and 55 patients in the <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\u2010negative non\u2010infection group (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> &lt; 0.3 mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>). Levels of presepsin and procalcitonin in the infection group were highest and significantly higher than those in the <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\u2010positive non\u2010infection group (presepsin 682.8 \u00b1 158.1 pg\/<jats:styled-content style=\"fixed-case\">mL <\/jats:styled-content><jats:italic>vs<\/jats:italic>. 192.0 \u00b1 12.0 pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> [<jats:italic>P<\/jats:italic> &lt; 0.0001]; procalcitonin 4.052 \u00b1 1.637 ng\/<jats:styled-content style=\"fixed-case\">mL <\/jats:styled-content><jats:italic>vs<\/jats:italic>. 0.120 \u00b1 0.032 ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> [(<jats:italic>P<\/jats:italic> &lt; 0.0001]). According to receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analysis, presepsin and procalcitonin levels appeared to have a higher diagnostic accuracy for infection than <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>. For the infection group, the <jats:styled-content style=\"fixed-case\">SOFA<\/jats:styled-content> Score positively correlated with the concentration of presepsin but not with that of procalcitonin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presepsin and procalcitonin may be useful to identify infection in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients. Presepsin may better reflect infection severity than procalcitonin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12899","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T09:26:45Z","timestamp":1465810005000},"page":"1406-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Presepsin and procalcitonin as biomarkers of systemic bacterial infection in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-2983","authenticated-orcid":false,"given":"Kohei","family":"Tsujimoto","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"},{"name":"Department of Infectious Diseases Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Hatachi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yagita","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009741003604542"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21649"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-10"},{"key":"e_1_2_8_5_1","first-page":"114","article-title":"Diagnostic accuracy of serum procalcitonin concentrations for detecting systemic bacterial infection in patients with systemic autoimmune diseases","volume":"35","author":"Tamaki K","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_8_6_1","first-page":"451","article-title":"Procalcitonin in bacterial infections\u2013hype, hope, more or less?","volume":"135","author":"Christ\u2010Crain M","year":"2005","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_8_7_1","first-page":"123","article-title":"Diagnostic value of procalcitonin measurement in febrile patients with systemic autoimmune diseases","volume":"24","author":"Scir\u00e8 CA","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu416"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111601"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0435-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2013.07.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.051"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5847\/wjem.j.issn.1920-8642.2014.01.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13183"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3514-2"},{"key":"e_1_2_8_16_1","unstructured":"Centers for Disease Control and Prevention.Surveillance Definitions CDC\/NHSN Surveillance Definitions for Specific Types of Infections.http:\/\/www.cdc.gov\/nhsn\/PDFs\/pscManual\/17pscNosInfDef_current.pdfJanuary 2015 (Modified April 2015)"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.14.1754"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1601"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.05.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13070"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12899","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:34:11Z","timestamp":1695011651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/1756-185X.12899"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12899","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]},"assertion":[{"value":"2016-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}