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This study aimed to evaluate the effect of intravenous lidocaine on pain intensity, clinical manifestations and plasma levels of interleukin (\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      )\u20101,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106, and\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 in fibromyalgia patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a randomized double\u2010blind study, group 1 patients received 240 mg of lidocaine in 125\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      of saline solution, while group 2 patients received 125\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      of saline, both once a week for 4 weeks (T1, T2, T3 and T4). All patients received amitriptyline. The following were assessed: pain intensity before treatment (T0) and at 1, 2, 3, 4 and 8 weeks after treatment; clinical manifestations; the fibromyalgia impact questionnaire (\n                      <jats:styled-content style=\"fixed-case\">FIQ<\/jats:styled-content>\n                      ) before and at 4 and 8 weeks after; the levels of\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      1, 6 and 8 before and at 4 and 8 weeks after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lower pain intensity was observed in the lidocaine group at T2, with no difference at the other time points. There was a reduction in pain intensity in both groups. The use of paracetamol and tramadol and plasma levels of\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20101,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106 and\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 did not differ between the groups. Clinical manifestations and side effects did not differ between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.12904","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T08:54:01Z","timestamp":1466067241000},"page":"946-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of\n                    <scp>IL<\/scp>\n                    \u20101,\n                    <scp>IL<\/scp>\n        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