{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:38:20Z","timestamp":1790890700131,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Turkish Rheumatology Society","award":["RAED AD-100"],"award-info":[{"award-number":["RAED AD-100"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cognitive dysfunction is a neurologic manifestation in primary Sj\u00f6gren syndrome (<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>). On the other hand, several antibodies are related to cognitive dysfunction. The aim of this study is to assess the cognitive dysfunction of <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> patients via detailed neurologic tests. Moreover, its associations with antibodies were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010eight female patients with <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> and 17 healthy controls comprised the study groups. Short\u2010term memory, long\u2010term memory, verbal learning, visual memory, visual spatial perception, attention, verbal frequency function, executive functions and information processing speed were evaluated with neurologic tests in both of the study groups. Furthermore, anti\u2010<jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate (<jats:styled-content style=\"fixed-case\">NMDA<\/jats:styled-content>) type anti\u2010glutamate\u2010receptor antibody, anti\u2010ribosomal\u2010p and antiganglioside antibodies were assessed in the study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The attention, data processing speed, verbal learning, short\u2010term verbal memory and visuo\u2010spatial perception performances were lower in the patients with <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> when compared to the healthy controls. The difference reached statistical significance in Paced Auditory Serial Addition Test (<jats:italic>P<\/jats:italic> &lt; 0.01), Serial Digit Learning Test (<jats:italic>P<\/jats:italic> &lt; 0.01), clock drawing (<jats:italic>P<\/jats:italic> = 0.03), Auditory Verbal Learning Test immediate verbal memory (<jats:italic>P<\/jats:italic> = 0.01) and Benton Judgement of Line Orientation Test (<jats:italic>P<\/jats:italic> = 0.03). Even if antiganglioside antibodies were more likely to be present in the <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> group when compared to the healthy controls, no relationship was found between its positivity and cognitive dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results of this study suggest that cognitive dysfunction is quite prevalent in <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> patients without being associated with studied antibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12912","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T13:52:57Z","timestamp":1469454777000},"page":"981-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Primary Sj\u00f6gren's syndrome is associated with significant cognitive dysfunction"],"prefix":"10.1111","volume":"19","author":[{"given":"Mehmet Engin","family":"Tezcan","sequence":"first","affiliation":[{"name":"Department of Rheumatology Lutfi Kirdar Kartal Education and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Belgin","family":"Kocer","sequence":"additional","affiliation":[{"name":"Department of Neurology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seminur","family":"Haznedaroglu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemile","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Public Health Institution of Turkey Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridvan","family":"Mercan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul Atak","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Immunology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyla","family":"Irkec","sequence":"additional","affiliation":[{"name":"Department of Neurology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berivan","family":"Bitik","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Goker","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_8_3_1","first-page":"247","article-title":"The epidemiology of Sjogren's syndrome","volume":"6","author":"Patel R","year":"2014","journal-title":"Clin Epidemiol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21610"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000141099.53742.16"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833de6ab"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1458-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01293.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.098301"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0153-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.090811"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu497oa"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22031"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314555538"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.14581\/jer.13013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23411"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514534953"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312436856"},{"key":"e_1_2_8_20_1","first-page":"556","article-title":"Anti\u2010GM1 and anti\u2010sulfatide antibodies in patients with systemic lupus erythematosus, Sjogren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis","volume":"25","author":"Alpa M","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.07.014"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22658"},{"key":"e_1_2_8_24_1","first-page":"257","volume-title":"Bilrot bataryas\u0131 el kitab\u0131: N\u00f6ropsikolojik testler i\u00e7in ara\u015ft\u0131rma ve geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131","author":"Karaka\u015f S","year":"2004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)45:5<419::AID-ART360>3.0.CO;2-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550200074013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00300.x"},{"key":"e_1_2_8_28_1","volume-title":"Contributions to neuropsychological assesment: a clinical manual","author":"Benton AL","year":"1983"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084605"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170135"},{"key":"e_1_2_8_32_1","first-page":"29","article-title":"Neurological involvement in primary Sjogren syndrome","volume":"38","author":"Teixeira F","year":"2013","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07029.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.5.422"},{"key":"e_1_2_8_35_1","first-page":"135","article-title":"Anti\u2010ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: clinical, serological, and HLA class II gene associations. European concerted action on the immunogenetics of SLE","volume":"27","author":"Galeazzi M","year":"2000","journal-title":"J Rheumatol"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T14:34:10Z","timestamp":1695738850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/1756-185X.12912"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12912","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]},"assertion":[{"value":"2016-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}