{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T21:08:10Z","timestamp":1786655290663,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009381","name":"International Medical University Research Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009381","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The main objective of this study is to elucidate the clinical significance of the SLC<\/jats:styled-content>2A9\/GLUT<\/jats:styled-content>9<\/jats:italic> rs11722228 polymorphism among male gout patients.<\/jats:p><\/jats:sec>Method<\/jats:title>We consecutively recruited all newly diagnosed male gout patients who were treatment\u2010naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age\u2010matched healthy male adults were employed as controls. All subjects were tested for the SLC<\/jats:styled-content>2A9\/GLUT<\/jats:styled-content>9<\/jats:italic> rs11722228 genotypes, serum uric acid (SUA<\/jats:styled-content>), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 73 male gout patients and 73 age\u2010matched healthy male adults were recruited in this study. The genotypic frequencies of SLC<\/jats:styled-content>2A9\/GLUT<\/jats:styled-content>9<\/jats:italic> rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC<\/jats:styled-content> genotype had significantly higher SUA<\/jats:styled-content> levels (P<\/jats:italic> = 0.002), family history of gout (P<\/jats:italic> < 0.050) and the occurrence of renal calculi (P<\/jats:italic> = 0.026). The SUA<\/jats:styled-content>\u2010adjusted odds ratios (OR<\/jats:styled-content>) of the occurrence of renal calculi in the CC<\/jats:styled-content> genotype (OR<\/jats:styled-content> = 1 [reference]) was significantly higher than the CT<\/jats:styled-content> genotype (OR<\/jats:styled-content> = 0.338, 95%CI<\/jats:styled-content>: 0.141\u20130.813) and the TT<\/jats:styled-content> genotype (OR<\/jats:styled-content> = 0.271, 95%CI<\/jats:styled-content>: 0.086\u20130.854).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The genotypic distribution of SLC<\/jats:styled-content>2A9\/GLUT<\/jats:styled-content>9<\/jats:italic> rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC<\/jats:styled-content> genotype in gout had significant associations with higher levels of SUA<\/jats:styled-content>, renal calculi and a positive family history of gout.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12918","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T07:47:45Z","timestamp":1469519265000},"page":"705-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical significance of SLC<\/scp>2A9\/GLUT<\/scp>9<\/i> rs11722228 polymorphisms in gout"],"prefix":"10.1111","volume":"21","author":[{"given":"Esha","family":"Das Gupta","sequence":"first","affiliation":[{"name":"Department of Medicine International Medical University Seremban Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalingham","family":"Sakthiswary","sequence":"additional","affiliation":[{"name":"Department of Medicine Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing L.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine International Medical University Seremban Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shew F.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine International Medical University Seremban Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heselynn","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Medicine Putrajaya Hospital Wilayah Persekutuan Putrajaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk C.","family":"Gun","sequence":"additional","affiliation":[{"name":"Department of Medicine Tuanku Jaafar Hospital Seremban Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6195"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2012.07.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030194"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61343-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.11.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904411106"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.04.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90441-4"},{"key":"e_1_2_6_11_1","first-page":"497","article-title":"Epidemiological survey of hyperuricemia as an adverse reaction to antituberculous therapy with pyrazinamide","volume":"83","author":"Taki H","year":"2008","journal-title":"Kekkaku"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009040406"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr419"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-31-4-595"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2500"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2014.01.009"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12918","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T08:31:05Z","timestamp":1695630665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/1756-185X.12918"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12918","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]},"assertion":[{"value":"2016-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}