{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:25:37Z","timestamp":1762521937448},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Data regarding the clinical and radiographic hand involvement in Asian patients with systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) are limited. Thus, we determined the prevalence of clinical and radiographic hand involvement in Thai <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients, comparing diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) and limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c). We also determined the factors associated with arthritis, contracture of fingers and digital ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients seen at the Rheumatology Clinic, Chiang Mai University, Thailand, from December 2012 to June 2013 were consecutively invited to enroll in the study. After study entry, demographic data, clinical features and hand radiographs were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>We studied 110 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients (73 dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) with mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age of 53.2\u00a0\u00b1\u00a09.2\u00a0years and disease duration from non\u2010Raynaud's phenomenon of 4.9\u00a0\u00b1\u00a04.8\u00a0years. The prevalence of arthritis, finger contractures and digital ulcers were 10 (9.1%), 47 (42.7%), and 14 (12.7%), respectively. DcSSc patients had significantly more of the following hand complications than lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients: digital pitting scar (53.4% <jats:italic>vs<\/jats:italic>. 27.0%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008), digital ulcer (17.8% <jats:italic>vs<\/jats:italic>. 2.7%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032), traumatic ulcer (27.4% <jats:italic>vs<\/jats:italic>. 0%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), acrolysis (45.2% <jats:italic>vs<\/jats:italic>. 18.9%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007) and flexion contracture (60.3% <jats:italic>vs<\/jats:italic>. 8.1%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Radiographic finger contractures were more prevalent in the dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c subset. In multivariate logistic regression analysis, a positive rheumatoid factor was associated with arthritis; dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, arthritis and modified Rodnan skin score (<jats:styled-content style=\"fixed-case\">MRSS<\/jats:styled-content>) &gt;\u00a018 were associated with contracture of fingers. Furthermore, hand <jats:styled-content style=\"fixed-case\">MRSS<\/jats:styled-content> &gt;\u00a04 was associated with digital ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirm that dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients had more severe clinical hand complications than lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. However, radiographic findings were similar among subgroups, except that more finger contractures were seen in dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Finally, the presence of rheumatoid factor is associated with arthritis, and high <jats:styled-content style=\"fixed-case\">MRSS<\/jats:styled-content> is associated with finger contractures and digital ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12919","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T07:53:22Z","timestamp":1469519602000},"page":"240-248","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and predictors of hand involvement in Thai patients with systemic sclerosis"],"prefix":"10.1111","volume":"21","author":[{"given":"Suparaporn","family":"Wangkaew","sequence":"first","affiliation":[{"name":"Division of Rheumatology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chate","family":"Sivasomboon","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Radiology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wit","family":"Leungwatthananon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuntana","family":"Kasitanon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Worawit","family":"Louthrenoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"721","article-title":"Employment across chronic inflammatory rheumatic diseases and comparison with the general population","volume":"32","author":"Mau W","year":"2005","journal-title":"J\u00a0Rheumatol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790040106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044602"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.780095"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130900"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091165"},{"key":"e_1_2_8_8_1","first-page":"101","article-title":"The arthropathy of systemic sclerosis (scleroderma); 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