{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:44:22Z","timestamp":1694756662885},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary thromboembolism (<jats:styled-content style=\"fixed-case\">PTE<\/jats:styled-content>) is rarely reported in Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) due to its distinctive thrombus\u2010forming mechanism. In <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, the inflammation on vessel walls causes venous thrombosis. The thrombi are considered to be tethered to the inflamed walls making embolization less frequent. Thus, immunosuppressive agents are the mainstay of treatment. However, the necessity of anticoagulation therapy is controversial because of its uncertain efficacy of resolving thrombi and the possibility of fatal side effects of hemorrhage. A 25\u2010year\u2010old man with recurrent oral aphthae visited with abrupt onset of dyspnea and chest pain. Based on history, imaging studies and laboratory results, he was diagnosed with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> with vascular involvement and antiphospholipid syndrome (<jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>), causing <jats:styled-content style=\"fixed-case\">PTE<\/jats:styled-content> from deep vein thrombosis. The co\u2010existing <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content> may have further promoted the thrombosis, shifting his blood profile toward the hypercoagulable state. Immunosuppressive therapy with glucocorticoid and azathioprine, and concomitant anticoagulation with warfarin were achieved successfully without any fatal complications. When atypical features of vascular involvement in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> develop, other coexisting diseases should be considered to design an optimal therapeutic plan.<\/jats:p>","DOI":"10.1111\/1756-185x.12923","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T08:07:05Z","timestamp":1469520425000},"page":"2188-2192","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary thromboembolism in patient with coexistence of Beh\u00e7et's disease and antiphospholipid syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"Jun\u2010Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Konkuk University Medical Center Seoul 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