{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:02:24Z","timestamp":1760608944999},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to investigate the therapeutic advantage of administering tacrolimus (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) in patients with polymyositis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) and dermatomyositis (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical outcomes after initiating treatment in 66 patients with <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> (28 <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> and 38 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>). After initiating treatment, the prognosis was compared between patients who received <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> in combination with prednisolone (<jats:styled-content style=\"fixed-case\">PSL<\/jats:styled-content>) (the concomitant <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group), and patients who were treated with <jats:styled-content style=\"fixed-case\">PSL<\/jats:styled-content> alone. The therapeutic efficacy of <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> was also evaluated for patients in the concomitant <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group as well as patients who started additional <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> treatment after relapse (the additional <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group), by analyzing clinical results, including serum creatine kinase (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>) levels, muscle strength and the daily dose of <jats:styled-content style=\"fixed-case\">PSL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the concomitant <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group had significantly lower frequency of relapse and longer periods of remission than patients who were treated with <jats:styled-content style=\"fixed-case\">PSL<\/jats:styled-content> alone (<jats:italic>P<\/jats:italic> = 0.0001, <jats:italic>P<\/jats:italic> = 0.001, respectively). Significant decreases in <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> levels were observed 1 month after starting <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> treatment in both the concomitant <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group and the additional <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group. Moreover, the significant effects of withdrawing <jats:styled-content style=\"fixed-case\">PSL<\/jats:styled-content> were also demonstrated in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Concomitant use of <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">PSL<\/jats:styled-content> clearly provides a favorable outcome in patients with <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>. Furthermore, additional treatment with <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> is useful for improving prognosis even after recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12931","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T08:58:48Z","timestamp":1469523528000},"page":"1322-1330","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis"],"prefix":"10.1111","volume":"19","author":[{"given":"Ken\u2010ichi","family":"Ueno","sequence":"first","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of 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