{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:57:30Z","timestamp":1769273850217,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the efficacy and safety of technetium\u201099 conjugated with methylene diphosphonate (<jats:sup>99<\/jats:sup>Tc\u2010MDP, Yunke Pharmaceutical industry) in the treatment of rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 120 patients with active RA were randomly divided into three groups: Group A (receiving oral meloxicam tablets); Group B (receiving intravenous drip of <jats:sup>99<\/jats:sup>TC\u2010MDP); Group C (receiving combination treatment of intravenous drip of <jats:sup>99<\/jats:sup>Tc\u2010MDP and oral meloxicam tablets). The main clinical and laboratory parameters were evaluated at baseline and after 14 days of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 14 days of treatment, American College of Rheumatology 20 response was 15.62%, 34.04% and 48.78% in the three groups, respectively. The incidence of adverse events in three groups were 3.13%, 8.51% and 9.76% respectly, and has no significant difference. In addition, biochemical markers of bone metabolism including bone alkaline phosphatase (BAP), tartrate resistant acid phosphatase (TRAP) and dickkopf\u20101 (DKK\u20101), all improved in the three groups, although more significant in Group B than Group A, and more significant in the combination group than monotherapy groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sup>99<\/jats:sup>Tc\u2010MDP has good efficacy and safety in the treatment of active RA patients; the benefit was more remarkable when <jats:sup>99<\/jats:sup>Tc\u2010MDP was combined with NSAIDs. <jats:sup>99<\/jats:sup>Tc\u2010MDP may also have potential to improve bone metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12934","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T20:20:22Z","timestamp":1486153222000},"page":"161-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A randomized multicenter clinical trial of <sup>99<\/sup>Tc\u2010methylene diphosphonate in treatment of rheumatoid arthritis"],"prefix":"10.1111","volume":"21","author":[{"given":"Rong","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Rheumatology &amp; Immunology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Immunology the Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 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