{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:38:35Z","timestamp":1770748715345,"version":"3.50.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to evaluate the diagnostic yield of dual\u2010energy computed tomography (<jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content>) in detection of uric acid accumulation in joints or periarticular structures in patients suspected of having gout, in their intercritical period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a history of recurrent, short\u2010lived mono\u2010 or oligo\u2010arthralgia or arthritis, referred to the rheumatology clinic for diagnosis of their condition, were included in this retrospective evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content> confirmed the diagnosis of gout in 30 of 50 patients (60%). A positive <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content> was present in 12 of 16 cases (75%) with serum uric acid &gt; 8.5 mg\/dL, compared to seven of 13 cases (54%) and two of five cases (40%) with levels of 6.1\u20138.5 mg\/dL and \u2264 6 mg\/dL, respectively. The diagnostic impact of screening hands and feet were highest (78% and 56%, respectively). Follow\u2010up data were available for 24 of the 30 patients with urate deposits identified by <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content>. Twenty\u2010one were treated with urate\u2010lowering agents, all responded with lowering of serum uric acid and cessation of flares. Follow\u2010up data were available for 16 of the 20 patients with no urate deposits identified by <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content>. Gout was diagnosed in two of them by synovial fluid examination during subsequent flares. Both positive and negative predictive values of <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content> for diagnosing gout in this patient population were 87%. Following <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content>, treatment regimen was modified to gout\u2010specific therapy in 52% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The ability to make a definite diagnosis of gout by <jats:styled-content style=\"fixed-case\">DECT<\/jats:styled-content> imaging in a substantial number of asymptomatic patients in the intercritical period should help in treatment decision\u2010making and improve patient adherence to long\u2010term urate\u2010lowering therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12938","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T10:12:48Z","timestamp":1469527968000},"page":"1337-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dual\u2010energy computed tomography as a diagnostic tool for gout during intercritical periods"],"prefix":"10.1111","volume":"19","author":[{"given":"Gabriel S.","family":"Breuer","sequence":"first","affiliation":[{"name":"Rheumatology Unit Department of Medicine Shaare Zedek Medical Center Hebrew University School of Medicine Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naama","family":"Bogot","sequence":"additional","affiliation":[{"name":"Department of Radiology Shaare Zedek Medical Center Hebrew University School of Medicine Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Nesher","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Medicine Shaare Zedek Medical Center Hebrew University School of Medicine Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076232"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055251"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102014\u2013205431"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205095"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102485"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200976"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket341"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.154054"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206397"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.11.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204273"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.10.019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4237-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39254"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579709"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.12938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.12938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:19:57Z","timestamp":1696346397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.12938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/1756-185X.12938"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.12938","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]},"assertion":[{"value":"2016-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}