{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:44:47Z","timestamp":1792241087337,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aim to report the clinical manifestations, genetic testing results, magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) findings and biologics used in the management of non\u2010bacterial osteomyelitis in our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of medical records. A previously proposed classification was implemented as follows: chronic recurrent multifocal osteomyelitis (<jats:styled-content style=\"fixed-case\">CRMO<\/jats:styled-content>), chronic non\u2010bacterial osteomyelitis (<jats:styled-content style=\"fixed-case\">CNBO<\/jats:styled-content>) and acute non\u2010bacterial osteomyelitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four females and three males with a median age at presentation of 6 years (6 months\u201314 years) presented with arthralgia (7\/7), back pain (4\/7), arthritis (4\/7) and bone pain (2\/7). Six patients had <jats:styled-content style=\"fixed-case\">CRMO<\/jats:styled-content> and one patient had <jats:styled-content style=\"fixed-case\">CNBO<\/jats:styled-content>. Genetic testing revealed an apparent homozygote p.S734L <jats:italic><jats:styled-content style=\"fixed-case\">LPIN<\/jats:styled-content>2<\/jats:italic> mutation in two siblings, a heterozygote p.M694V <jats:italic><jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content><\/jats:italic> mutation in one patient with familial Mediterranean fever and heterozygote p.Q219H <jats:italic><jats:styled-content style=\"fixed-case\">PSTPIPI<\/jats:styled-content><\/jats:italic> variant of unknown significance in one patient. The most common lesions on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> involved the tibia (6\/7), talar bones (5\/7), fibula (4\/7) and sacroiliac joints (4\/7). Three patients received infliximab. Two are in remission after 2 and 5 years, and the third was advanced after 5 years to canakinumab. Two other patients received canakinumab first. One patient with Majeed syndrome and dyserythropoietic anemia exhibited evidence of improvement, and one had partial improvement and was then treated with infliximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010bacterial osteomyelitis may coexist with other autoinflammatory diseases. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> remains a favorable diagnostic tool and genetic testing may have a limited role in selected cases. Infliximab and canakinumab are associated with variable outcomes, and 6\u2010week or less dosing intervals for both medications may be more effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12940","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T08:47:19Z","timestamp":1478767639000},"page":"1286-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Clinical and genetic association, radiological findings and response to biological therapy in seven children from Qatar with non\u2010bacterial osteomyelitis"],"prefix":"10.1111","volume":"20","author":[{"given":"Taha","family":"Moussa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hamad General Hospital Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatraman","family":"Bhat","sequence":"additional","affiliation":[{"name":"Imaging Services Narayana Multispecialty 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