{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:01:18Z","timestamp":1776736878212,"version":"3.51.2"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this study is the evaluation of the effect of vitamin D replacement treatment on musculoskeletal symptoms and quality of life in patients with chronic widespread musculoskeletal pain (CWP) including fibromyalgia (FM) and vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with nonspecific CWP and vitamin D deficiency (25\u2010OH D3\u00a0&lt;\u00a025\u00a0ng\/mL) were included into the study. Replacement treatments of 50\u00a0000\u00a0IU\/week oral vitamin D3 for 3\u00a0months were given to the patients. Patients were assessed pre\u2010 and post\u2010treatment in terms of serum levels of Ca, P, alkaline phosphatase, 25\u2010OH D3, severity of pain (visual analogue scale [VAS]\u2010pain), severity of asthenia (VAS\u2010asthenia), Beck Depression Inventory (BDI), quality of life scale (Short Form [SF]\u201036), tender point count (TPC), severity of waking unrefreshed, headache, tenderness on tibia, meeting the criteria of FM, and level of patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight patients with a mean age of 36.9\u00a0\u00b1\u00a09.2\u00a0years were included into the study. 25\u2010OH D3 levels of patients elevated from 10.6\u00a0\u00b1\u00a05.1\u00a0ng\/mL to 46.5\u00a0\u00b1\u00a024.0\u00a0ng\/mL after replacement treatment (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Marked decrease in VAS\u2010pain, VAS\u2010asthenia, severity of waking unrefreshed, TPC, and BDI and an evident increase in subgroups of SF\u201036 were established in patients after treatment (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). The number of FM+ patients was 30 (52%) before treatment and regressed to 20 (34%) after treatment (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.013); 85% of patients stated satisfaction with the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin D replacement treatment in patients with nonspecific CWP has provided improvements in musculoskeletal symptoms, level of depression and quality of life of patients. Patients with CWP should be investigated for vitamin D deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12960","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T01:00:47Z","timestamp":1479171647000},"page":"1255-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency"],"prefix":"10.1111","volume":"19","author":[{"given":"Ramazan","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Yoncali Physical Medicine and Rehabilitation Hospital Kutahya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Salli","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Meram Medical School Necmettin Erbakan 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