{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:58:42Z","timestamp":1780599522792,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate etanercept in patients from Latin America, Central\/Eastern Europe, and Asia with non\u2010radiographic axial spondyloarthritis (nr\u2010axSpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A subset analysis was performed on nr\u2010axSpA patients from Argentina, Colombia, the Czech Republic, Hungary, Russia and Taiwan who were enrolled in <jats:styled-content style=\"fixed-case\">EMBARK<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01258738). Patients received either etanercept 50 mg or placebo once weekly. The primary endpoint was proportion of patients achieving 40% improvement from baseline based on Assessment of SpondyloArthritis International Society (<jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content>) criteria. Secondary endpoints included other efficacy assessments, health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 117 patients in this subset, 59 were treated with etanercept and 58 received placebo. At week 12, numerically greater improvements from baseline were observed for all efficacy endpoints in etanercept\u2010treated patients compared with those receiving placebo. Statistically significant differences between the two treatment groups were observed for proportion of patients achieving <jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content>40 (<jats:italic>P<\/jats:italic> = 0.0413, at week 8), <jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content>5\/6 (<jats:italic>P<\/jats:italic> = 0.0126), Ankylosing Spondylitis Disease Activity Score \u2010 C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) inactive disease (<jats:italic>P<\/jats:italic> = 0.0093), Spondyloarthritis Research Consortium of Canada magnetic resonance imaging of sacroiliac joint scores (<jats:italic>P<\/jats:italic> = 0.0014), high\u2010sensitivity <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=0.032), and erythrocyte sedimentation rate (<jats:italic>P<\/jats:italic> = 0.0082). Statistically significant improvements in the etanercept\u2010treated group compared with placebo group were observed for nocturnal back pain (<jats:italic>P<\/jats:italic> = 0.040), total back pain (<jats:italic>P<\/jats:italic> = 0.025), physician global assessment of disease (<jats:italic>P<\/jats:italic> = 0.023), and Work Productivity and Activity Impairment Questionnaire percent impairment while working (<jats:italic>P<\/jats:italic> = 0.047). Adverse events were similar between the two treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this subset of patients with nr\u2010axSpA from Latin America, Central\/Eastern Europe, and Asia, treatment with etanercept, compared with placebo, resulted in improved disease symptoms and patient <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. Etanercept was well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.12973","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T21:55:58Z","timestamp":1479160558000},"page":"1443-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of etanercept in patients from Latin America, Central Europe and Asia with early non\u2010radiographic axial spondyloarthritis"],"prefix":"10.1111","volume":"21","author":[{"given":"James Cheng\u2010Chung","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Institute of Integrated Medicine China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Kaohsiung Medical University Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Citera","sequence":"additional","affiliation":[{"name":"Instituto de Rehabilitaci\u00f3n Psicof\u00edsica Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Kotak","sequence":"additional","affiliation":[{"name":"Pfizer New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndon","family":"Llamado","sequence":"additional","affiliation":[{"name":"Pfizer Makati Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108217"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2013.37.5.675"},{"key":"e_1_2_7_7_1","first-page":"780","article-title":"Ankylosing spondylitis: an update","volume":"42","author":"Golder V","year":"2013","journal-title":"Aust Fam Physician"},{"issue":"5","key":"e_1_2_7_8_1","first-page":"S\u201096","article-title":"Optimisation of rheumatology assessments \u2013 the actual situation in axial spondyloarthritis including ankylosing spondylitis","volume":"32","author":"Braun J","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.078139"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075879"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21563"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.899351"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"1","article-title":"Non\u2010radiographic axial spondyloarthritis: what is it?","volume":"32","author":"Fianyo E","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130588"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044206"},{"key":"e_1_2_7_17_1","first-page":"1953","article-title":"Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. 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