{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T01:57:45Z","timestamp":1719107865005},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T00:00:00Z","timestamp":1488672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["910503"],"award-info":[{"award-number":["910503"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005013","name":"Academic Center for Education, Culture and Research","doi-asserted-by":"publisher","award":["2100\u201020"],"award-info":[{"award-number":["2100\u201020"]}],"id":[{"id":"10.13039\/501100005013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Human T lymphotropic virus type 1 (<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101) infection with high prevalence in the north\u2010east of Iran, particularly in Mashhad, can lead to adult T\u2010cell leukemia (<jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101\u2010associated myelopathy\/tropical spastic paraparesis (<jats:styled-content style=\"fixed-case\">HAM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>) and a variety of autoimmune diseases. The aim of the study was to examine the presence of autoimmune markers in <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content> carries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples were obtained from blood donors in Mashhad, northeastern Iran. One hundred and five <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 positive (cases) and 104 age\u2010 and sex\u2010matched <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 negative donors (controls) were assessed for presence of serum autoimmune markers by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean ages of cases and controls were 40.8 \u00b1 9.4 and 41.5 \u00b1 9.3 years, respectively (<jats:italic>P<\/jats:italic> = 0.5). In the case group, 81.9% and in the control group 83.7% were male (<jats:italic>P<\/jats:italic> = 0.74). The frequency of positive antinuclear antibodies and anticyclic citrullinated peptide antibodies in the serum of the two groups were not significantly different (<jats:italic>P<\/jats:italic> = 0.68 and <jats:italic>P<\/jats:italic> = 0.62, respectively). Only one antineutrophil cytoplasmic antibody\u2010positive case (1%) was observed in the group and no anti\u2010phospholipid immunoglobulin G positivity was observed. The frequency of rheumatoid factor (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>) was greater in case group than in the control group, although the difference was not significant (<jats:italic>P<\/jats:italic> = 0.08). The amount of <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> in all 12 <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> positive sera were higher than normal levels (33\u201337 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because we failed to detect any significant relation between serum autoimmune markers and <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 infection, and because of the relatively low prevalence of autoimmune diseases, it could be concluded that healthy <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 carriers do not produce rheumatologic\u2010related auto\u2010antibodies more than the healthy population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13002","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T02:02:52Z","timestamp":1488765772000},"page":"108-113","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rate of positive autoimmune markers in Human T lymphotropic virus type 1 carriers: a case\u2010control study from Iran"],"prefix":"10.1111","volume":"21","author":[{"given":"Sanaz","family":"Ahmadi Ghezeldasht","sequence":"first","affiliation":[{"name":"Blood Borne Infections Research Center Academic Center for Education Culture and Research (ACECR), Razavi Khorasan Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Hedayati\u2010Moghaddam","sequence":"additional","affiliation":[{"name":"Blood Borne Infections Research Center Academic Center for Education Culture and Research (ACECR), Razavi Khorasan Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meysam","family":"Habibi","sequence":"additional","affiliation":[{"name":"Blood Borne Infections Research Center Academic Center for Education Culture and Research (ACECR), Razavi Khorasan Mashhad Iran"},{"name":"Rheumatic Diseases Research Centre School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzad","family":"Mollahosseini","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine and Razavi Khorasan Blood Transfusion Center Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houshang","family":"Rafatpanah","sequence":"additional","affiliation":[{"name":"Inflammation and Inflammatory Diseases Research Centre School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahele","family":"Miri","sequence":"additional","affiliation":[{"name":"Blood Borne Infections Research Center Academic Center for Education Culture and Research (ACECR), Razavi Khorasan Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MohammadReza","family":"Hatef Fard","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research Centre School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sahebari","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research Centre School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/322130a0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208968"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.07.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.15"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.0140"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1001.020714"},{"key":"e_1_2_10_9_1","first-page":"252","article-title":"Is there any association between human lymphotropic virus type I (HTLV\u2010I) infection and systemic lupus erythematosus? An original research and literature review","volume":"16","author":"Shirdel A","year":"2013","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.6.769"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90630-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.103429"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict The development of rheumatoid arThritis","volume":"48","author":"Rantapaah\u2010Dahlquvist S","year":"2003","journal-title":"Arthritis Rheum"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0246-x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis273"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bba9"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.156919"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/430064"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340612"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847731"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1996.741562.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06597.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2001.2415"},{"key":"e_1_2_10_24_1","first-page":"936","article-title":"T lymphocyte apoptosis in systemic lupus erythematosus patients","volume":"16","author":"Rastin M","year":"2013","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.57"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2169\/internalmedicine.38.512","article-title":"Human T cell leukemia virus type I\u2010associated myelopathy in a patient with systemic lupus erythematosus","volume":"38","author":"Miura T","year":"1999","journal-title":"Intern Med"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00456.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91793-5"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2169\/internalmedicine.35.624","article-title":"Autoantibodies and immunoglobulins in atomic bomb survivors with human T\u2010lymphotropic virus type I","volume":"35","author":"Ohishi K","year":"1996","journal-title":"Intern Med"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.3.193"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s007050050192","article-title":"Antinuclear autoantibodies in human T\u2010cell leukemia\/lymphoma virus type I carriers in French Guiana","volume":"142","author":"Talarmin A","year":"1997","journal-title":"Arch Virol"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1066-5"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339500400210"},{"key":"e_1_2_10_34_1","first-page":"101","article-title":"HTLV\u20101 associated polymyositis in Jamaica","volume":"104","author":"Gilbert DTMO","year":"2001","journal-title":"ActaNeurol Scand"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T09:28:26Z","timestamp":1695893306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,5]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/1756-185X.13002"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13002","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,5]]},"assertion":[{"value":"2017-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}