{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:26:14Z","timestamp":1764174374885},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T00:00:00Z","timestamp":1488672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172857","81373188"],"award-info":[{"award-number":["81172857","81373188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2011AA02A113"],"award-info":[{"award-number":["2011AA02A113"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Takayasu arteritis (TA<\/jats:styled-content>) is a rare autoimmune disease with ethnic differences. Genome\u2010wide association studies (GWAS<\/jats:styled-content>) showed novel genetic variants in the human leukocyte antigen (HLA<\/jats:styled-content>) region were associated with TA<\/jats:styled-content>. The present study aimed to investigate the linkage between these single nucleotide polymorphisms (SNP<\/jats:styled-content>) and TA<\/jats:styled-content> in a Chinese Han population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Four hundred and twelve patients from multiple centers and 597 healthy controls were genotyped using the Sequenom MassArray iPLEX<\/jats:styled-content> platform. The association between these SNP<\/jats:styled-content>s and various clinical symptom of TA<\/jats:styled-content> was also investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>Our study showed a higher risk allele frequency of rs12524487 in TA<\/jats:styled-content> patients compared to healthy controls (26.6% vs<\/jats:italic>. 21.7%, odds ratio [OR<\/jats:styled-content>] 1.31, 95% CI<\/jats:styled-content> 1.06\u20131.61). The other SNP<\/jats:styled-content> rs9366782 in HLA<\/jats:styled-content>\u2010B\/MICA<\/jats:styled-content> (major histocompatibility complex class I polypeptide\u2010related sequence A) showed association with TA<\/jats:styled-content> ischemic brain disease (OR<\/jats:styled-content>: 1.78, 95% CI<\/jats:styled-content>: 1.16\u20132.73, P<\/jats:italic>c<\/jats:sub> = 0.03). However, rs3763288 and rs114202986 in MICA<\/jats:styled-content> were negatively related to TA<\/jats:styled-content> either as a whole or in any clinical features. Meanwhile, ATGT<\/jats:styled-content>(rs9366782, rs12524487, rs3763288 and rs114202986) were the risk haplotypes (P<\/jats:italic>c<\/jats:sub> = 2.48 \u00d7 10\u221210<\/jats:sup>).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings indicated that rs12524487 in HLA<\/jats:styled-content>\u2010B\/MICA<\/jats:styled-content> was a genetic risk factor for TA<\/jats:styled-content> in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA<\/jats:styled-content> but not TA<\/jats:styled-content> susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13012","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T02:16:39Z","timestamp":1488766599000},"page":"271-277","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between genetic variants in the human leukocyte antigen\u2010B\/MICA<\/scp> and Takayasu arteritis in Chinese Han population"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaoting","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"},{"name":"Department of Clinical Laboratory Beijing Anzhen Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liubing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Anzhen Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College 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