{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:14:01Z","timestamp":1791598441697,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To clarify the relationship between active synovitis\/osteitis and subsequent residual synovitis (R\u2010synovitis) in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and twenty finger joints of 16 patients with active <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> at baseline (Disease Activity Score with 28 joints \u2013 erythrocyte sedimentation rate &gt; 3.2) who subsequently achieved clinical low disease activity or remission afterwards were analyzed. Synovial vascularity (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>) was assessed according to a semi\u2010quantitative ultrasound score (grades 0\u20133). Active synovitis was defined by <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> positivity at baseline. R\u2010synovitis was defined by the presence of grade &gt; 2 <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> at the 24th week. Osteitis was detected by magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) at baseline as trabecular bone lesions with water content and indistinct margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ultrasonography detected active synovitis in 116 joints at baseline. Forty\u2010seven joints had R\u2010synovitis at the 24th week. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> detected osteitis in 12 joints at baseline. The presence of active synovitis with osteitis at baseline was significantly correlated with R\u2010synovitis at the 24th week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Active synovitis in the presence of osteitis predicted R\u2010synovitis regardless of whether there was a clinical improvement in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13030","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T21:26:28Z","timestamp":1486157188000},"page":"1809-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Active synovitis in the presence of osteitis predicts residual synovitis in patients with rheumatoid arthritis with a clinical response to treatment"],"prefix":"10.1111","volume":"21","author":[{"given":"Jun","family":"Fukae","sequence":"first","affiliation":[{"name":"Hokkaido 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