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There were no significant differences in median <jats:styled-content style=\"fixed-case\">cFAP<\/jats:styled-content> between the three groups. <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> demonstrated a negative correlation with inflammatory markers and duration of disease. There were no associations with disease subtypes in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, including seropositive and erosive disease. Decreased <jats:styled-content style=\"fixed-case\">cDPP<\/jats:styled-content>4 was found in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with myositis. Plasma <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> was lower in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients receiving prednisone (<jats:italic>P<\/jats:italic> = 0.001) or leflunomide (<jats:italic>P<\/jats:italic> = 0.04), but higher with biologic agents (<jats:italic>P<\/jats:italic> = 0.01). <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients receiving leflunomide also had decreased <jats:styled-content style=\"fixed-case\">cDPP<\/jats:styled-content>4 (<jats:italic>P<\/jats:italic> = 0.014). <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients receiving prednisone (<jats:italic>P<\/jats:italic> = 0.02) had lower <jats:styled-content style=\"fixed-case\">cDPP<\/jats:styled-content>4 but there was no association with <jats:styled-content style=\"fixed-case\">cFAP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No association was found between <jats:styled-content style=\"fixed-case\">cFAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Plasma <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4 was decreased in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c when compared with controls. <jats:styled-content style=\"fixed-case\">cDPP<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">cFAP<\/jats:styled-content> correlated negatively with inflammatory markers and there were no significant correlations with disease characteristics in this <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13031","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T07:06:44Z","timestamp":1482131204000},"page":"1915-1923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Circulating fibroblast activation protein and dipeptidyl 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