{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:13:30Z","timestamp":1790115210756,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea","award":["HI15C2958"],"award-info":[{"award-number":["HI15C2958"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the relationship between circulating adiponectin and visfatin levels and rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) and to establish a correlation between serum adipokine levels and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted meta\u2010analyses on serum\/plasma adiponectin or visfatin levels in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and controls and correlation coefficients between circulating adiponectin and visfatin levels and Disease Activity Score of 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies comprising 813 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients and 684 controls were included in this meta\u2010analysis. The meta\u2010analysis revealed that adiponectin levels were significantly higher in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> group than in the control group (standardized mean difference [<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>] = 1.529, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] = 0.354\u22122.704, <jats:italic>P<\/jats:italic> = 0.011). Circulating adiponectin level was not associated with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> activity based on <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 and C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) levels. Visfatin levels were significantly higher in the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> group than in the control group (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content> = 2.575, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: = 0.963\u20134.189, <jats:italic>P<\/jats:italic> = 0.002). A trend of positive correlation among circulating visfatin levels and <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels was found (correlation coefficient = 0.416, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: = \u22120.917 to 0.795, <jats:italic>P<\/jats:italic> = 0.177; correlation coefficient = 0.366, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: = \u22120.074 to 0.687, <jats:italic>P<\/jats:italic> = 0.101, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis demonstrated that circulating adiponectin levels were significantly higher in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> than in controls. Circulating visfatin levels were significantly higher in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> than in controls and a positive correlation between circulating visfatin level and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> activity is suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13038","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T08:44:07Z","timestamp":1487234647000},"page":"664-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Circulating adiponectin and visfatin levels in rheumatoid arthritis and their correlation with disease activity: A meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Cheol","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005033221805"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei128"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2013.33181"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401534"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.409516"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.141"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5483"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0807581"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22833"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2899-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-011-0834-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4306"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1649-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080907"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24626"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080626"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-1074-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.09.002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046540"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9637-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0320-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309357763"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_7_27_1","unstructured":"WellsG SheaB O'ConnellDet al. 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