{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:48:26Z","timestamp":1777535306837,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Autoimmune thyroid disease (<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>) frequently coexists with other systemic autoimmune conditions such as rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) and systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>). Due to the overlapping and nonspecific nature of symptoms, it is difficult to clinically uncover thyroidal illnesses in<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>patients. This study was conducted to estimate the prevalence of thyroid dysfunction including the presence of anti\u2010thyroid peroxidase (anti<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>) autoantibodies in patients with<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>and to analyze symptomatology of thyroid dysfunction in patients diagnosed with<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This cross\u2010sectional, prospective study was conducted on 100 patients with<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, attending the Rheumatology Outpatient Department at St John's Medical College and Hospital, Bangalore, India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients had biochemical evidence of thyroid dysfunction, hypothyroidism being the commonest (15\/22 patients). Although fatigue and hair loss were the most common symptoms, only weight gain and cold intolerance were found to be statistically significant (<jats:italic>P<\/jats:italic>&lt; 0.05) predictors of hypothyroidism and 32 patients were anti<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>positive. It was observed that equal numbers of patients developed hypothyroidism after diagnosis of<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>and vice versa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>History taking at the bedside to elicit symptoms, especially weight gain and cold intolerance, is quintessential to ensure timely diagnosis of hypothyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13040","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T07:46:37Z","timestamp":1487576797000},"page":"688-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unravelling thyroid dysfunction in rheumatoid arthritis: History matters"],"prefix":"10.1111","volume":"21","author":[{"given":"Joseph","family":"Anoop","sequence":"first","affiliation":[{"name":"Department of Medicine AJ Institute of Medical Science Mangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Geetha","sequence":"additional","affiliation":[{"name":"Department of Medicine St. John's Medical College Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idiculla","family":"Jyothi","sequence":"additional","affiliation":[{"name":"Department of Medicine St. John's Medical College Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Rekha","sequence":"additional","affiliation":[{"name":"Department of Medicine St. John's Medical College Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineeta","family":"Shobha","sequence":"additional","affiliation":[{"name":"Division of Clinical immunology &amp; Rheumatology St. John's Medical College Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5257.909"},{"key":"e_1_2_6_3_1","first-page":"801","article-title":"Rheumatoid arthritis in Morocco","volume":"59","author":"Benamour S","year":"1992","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04809.x"},{"key":"e_1_2_6_5_1","first-page":"88","article-title":"Thyroid dysfunction in systemic lupus erythematosus and rheumatoid arthritis","volume":"12","author":"Porkodi R","year":"2004","journal-title":"J Indian Rheumatol Assoc"},{"key":"e_1_2_6_6_1","first-page":"430","volume-title":"Williams\u2019 Text Book of Endocrinology","author":"Larsen KS"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196302072680601"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.6.454"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5971.601"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.3.353"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.20452\/pamw.600","article-title":"Prevalence of thyroid diseases and antithyroid antibodies in women with rheumatoid arthritis","volume":"119","author":"Przygodzka M","year":"2009","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_6_13_1","first-page":"50","article-title":"Presence of thyroid disorders in patients with autoimmune and autoinflammatory rheumatic diseases","volume":"3","author":"Atalay S","year":"2016","journal-title":"Int Inv J Med Sci"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T14:19:40Z","timestamp":1749997180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/1756-185X.13040"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13040","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,20]]},"assertion":[{"value":"2017-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}