{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:27:44Z","timestamp":1761744464915},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastric antral vascular ectasia (<jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content>) continues to be a challenge in both diagnosis and treatment. <jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content> has a diverse group of associations and presumed causes, including cirrhosis, chronic renal failure and autoimmune connective tissue diseases. However, in most occasions, the management plan of <jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content> itself is the same whatever the underlying disease by using Argon plasma coagulation (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>). Herein, we will discuss three cases of systemic sclerosis\u2010associated <jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content> presenting with either acute or chronic gastrointestinal bleeding showing variable responses to <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>. Anemia and telangiectasia may be the first striking presentation of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c). Renal artery stenosis, aortic stenosis, widespread cutaneous and mucosal telangiectasia and hypertension seem to be associated with poor prognosis and should prompt rapid intervention and careful follow\u2010up. Moreover, the hunt for molecular underpinnings of the broad array of vascular lesions in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c has to include von Willebrand factor and endoglin. Eventually, we will review the recent alternatives that can be effective in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c\u2010<jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content>, such as band ligation, hematopoietic stem cells transplantation and immunotherapy.<\/jats:p>","DOI":"10.1111\/1756-185x.13047","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T07:42:44Z","timestamp":1487576564000},"page":"2133-2139","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gastric antral vascular ectasia in systemic sclerosis: Where do we stand?"],"prefix":"10.1111","volume":"20","author":[{"given":"Hala","family":"El\u2010Gendy","sequence":"first","affiliation":[{"name":"Rheumatology &amp; Clinical Immunology Unit Internal Medicine Department Faculty of Medicine Cairo University Cairo 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