{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:08:01Z","timestamp":1789945681329,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine and the Scleroderma Research Group, Khon Kaen University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Autoantibody profiles in systemic sclerosis (SS<\/jats:styled-content>c) and their relative clinical association vary between studies. The rate for being anti\u2010topoisomerase\u2010I (ATA<\/jats:styled-content>) positive and the association with diffuse cutaneous the SS<\/jats:styled-content>c subset (dcSS<\/jats:styled-content>c) is higher among Thais than among Caucasians. The objective was to evaluate the relevance of clinical presentation, namely being positive for one or more autoantibodies among Thai SS<\/jats:styled-content>c patients.<\/jats:p><\/jats:sec>Method<\/jats:title>A retrospective, cohort study was performed among SS<\/jats:styled-content>c patients over 18\u00a0years of age at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006 to December 2013. Autoantibodies comprising 13 SS<\/jats:styled-content>c\u2010specific antigens were evaluated using the EUROIMMUN AG<\/jats:styled-content> (L\u00fcbeck, Germany) in order to define their clinical association(s).<\/jats:p><\/jats:sec>Results<\/jats:title>Two hundred and eighty\u2010five scleroderma patients (200 female; 85 male) were included. The majority (66.7%) were dcSS<\/jats:styled-content>c subset. ATA<\/jats:styled-content> was the most common antibody profile in our patients (231 cases; 81.1%), followed by anti\u2010Ro 52 (87 cases; 30.5%). Eleven of our patients (3.9%) were negative for all antibody profiles and 44 cases (15.4%) were negative for ATA<\/jats:styled-content> and anti\u2010centromere antibody (anti\u2010CENP<\/jats:styled-content>). Almost 40% (112 cases) were positive for at least two autoantibodies. There was an association between the presence of ATA<\/jats:styled-content> and hand deformity (odds ratio [OR<\/jats:styled-content>] 3.94; 95% CI<\/jats:styled-content> 1.12\u201313.84), anti\u2010CENP<\/jats:styled-content> and hand deformity (OR<\/jats:styled-content> 0.20; 95% CI<\/jats:styled-content> 0.02\u20130.90), anti\u2010Ku and scleroderma\u2010polymyositis overlap syndrome (OR<\/jats:styled-content> 6.58; 95% CI<\/jats:styled-content> 2.16\u201319.39) and the absence of both ATA<\/jats:styled-content> and anti\u2010CENP<\/jats:styled-content> with female sex (OR<\/jats:styled-content> 2.90; 95% CI<\/jats:styled-content> 1.12\u20137.51), limited cutaneous SS<\/jats:styled-content>c subset (OR<\/jats:styled-content> 2.70; 95% CI<\/jats:styled-content> 1.30\u20135.55) and scleroderma\u2010polymyositis overlap syndrome (OR<\/jats:styled-content> 2.53; 95% CI<\/jats:styled-content> 1.04\u20136.16). Neither ATA<\/jats:styled-content> nor anti\u2010CENP<\/jats:styled-content> were associated with the SS<\/jats:styled-content>c subset.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>ATA<\/jats:styled-content> and anti\u2010CENP<\/jats:styled-content> were not helpful in differentiating the SS<\/jats:styled-content>c subset in Thai SS<\/jats:styled-content>c patients, albeit they were good for predicting hand function. Coexisting ATA<\/jats:styled-content> and anti\u2010CENP<\/jats:styled-content> negativity were associated with less extensive skin tightness and SS<\/jats:styled-content>c overlap syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13060","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T15:15:05Z","timestamp":1489158905000},"page":"1572-1581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais"],"prefix":"10.1111","volume":"20","author":[{"given":"Chingching","family":"Foocharoen","sequence":"first","affiliation":[{"name":"Department of Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyakarn","family":"Watcharenwong","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine 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