{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:13:28Z","timestamp":1782738808160,"version":"3.54.5"},"reference-count":90,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Rheum Dis"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1111\/1756-185x.13061","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T18:39:44Z","timestamp":1491417584000},"page":"131-140","source":"Crossref","is-referenced-by-count":99,"title":["Cholesterol metabolism in pathogenesis of osteoarthritis disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Saba","family":"Farnaghi","sequence":"first","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Science and Engineering Faculty; Queensland University of Technology; Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Crawford","sequence":"additional","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Science and Engineering Faculty; Queensland University of Technology; Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Science and Engineering Faculty; Queensland University of Technology; Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Prasadam","sequence":"additional","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Science and Engineering Faculty; Queensland University of Technology; Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"10.1111\/1756-185X.13061-BIB0001|apl13061-cit-0001","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.2005.045724","article-title":"Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study","volume":"66","author":"Dahaghin","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1111\/1756-185X.13061-BIB0002|apl13061-cit-0002","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ncprheum0423","article-title":"Risk factors and prognostic factors of hip and knee osteoarthritis","volume":"3","author":"Bierma-Zeinstra","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0003|apl13061-cit-0003","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/sj.mp.4001854","article-title":"Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease","volume":"11","author":"Martins","year":"2006","journal-title":"Molec Psychiatry"},{"key":"10.1111\/1756-185X.13061-BIB0004|apl13061-cit-0004","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cca.2011.10.019","article-title":"A comparative study of serum and synovial fluid lipoprotein levels in patients with various arthritides","volume":"413","author":"Oliviero","year":"2012","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0005|apl13061-cit-0005","first-page":"79","article-title":"Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"27","author":"Oliviero","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0006|apl13061-cit-0006","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0026-0495(93)90050-X","article-title":"Apolipoproteins A-I and B and cholesterol in synovial fluid of patients with rheumatoid arthritis","volume":"42","author":"Ananth","year":"1993","journal-title":"Metabolism"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0007|apl13061-cit-0007","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.matbio.2004.12.003","article-title":"Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression","volume":"24","author":"Gentili","year":"2005","journal-title":"Matrix Biol"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0008|apl13061-cit-0008","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.matbio.2004.02.002","article-title":"Expression of serum amyloid A in chondrocytes and myoblasts differentiation and inflammation: possible role in cholesterol homeostasis","volume":"23","author":"Zerega","year":"2004","journal-title":"Matrix Biol"},{"key":"10.1111\/1756-185X.13061-BIB0009|apl13061-cit-0009","first-page":"702","article-title":"Metabolic correlates of obesity and radiographic features of knee osteoarthritis: data from the Baltimore Longitudinal Study of Aging","volume":"24","author":"Martin","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0010|apl13061-cit-0010","first-page":"1118","article-title":"Association between metabolic factors and knee osteoarthritis in women: the Chingford Study","volume":"22","author":"Hart","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0011|apl13061-cit-0011","first-page":"1827","article-title":"The role of metabolic factors and blood pressure in the association of obesity with osteoarthritis of the knee","volume":"15","author":"Davis","year":"1988","journal-title":"J Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0012|apl13061-cit-0012","first-page":"1827","article-title":"Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study","volume":"25","author":"St\u00fcrmer","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0013|apl13061-cit-0013","first-page":"745","article-title":"Radiographic osteoarthritis and serum cholesterol","volume":"24","author":"Al-Arfaj","year":"2003","journal-title":"Saudi Med J"},{"key":"10.1111\/1756-185X.13061-BIB0014|apl13061-cit-0014","first-page":"1218","article-title":"Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in Goteborg","volume":"18","author":"Bagge","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0015|apl13061-cit-0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/ar2873","article-title":"Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women-a prospective cohort study","volume":"11","author":"Davies-Tuck","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/1756-185X.13061-BIB0016|apl13061-cit-0016","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/jor.21084","article-title":"Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes","volume":"28","author":"Tsezou","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1111\/1756-185X.13061-BIB0017|apl13061-cit-0017","doi-asserted-by":"crossref","first-page":"e35753","DOI":"10.1371\/journal.pone.0035753","article-title":"Central role of SREBP-2 in the pathogenesis of osteoarthritis","volume":"7","author":"Kostopoulou","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1111\/1756-185X.13061-BIB0018|apl13061-cit-0018","doi-asserted-by":"crossref","first-page":"e3740","DOI":"10.1371\/journal.pone.0003740","article-title":"Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks","volume":"3","author":"Iliopoulos","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1111\/1756-185X.13061-BIB0019|apl13061-cit-0019","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1002\/art.22876","article-title":"Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis","volume":"56","author":"Wu","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1111\/1756-185X.13061-BIB0020|apl13061-cit-0020","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.33443","article-title":"Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice","volume":"64","author":"Gierman","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1111\/1756-185X.13061-BIB0021|apl13061-cit-0021","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.joca.2013.02.144","article-title":"Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice-a translational model for atherosclerosis","volume":"21","author":"Gierman","year":"2013","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1111\/1756-185X.13061-BIB0022|apl13061-cit-0022","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.joca.2015.11.016","article-title":"High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis","volume":"24","author":"Munter","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/1756-185X.13061-BIB0023|apl13061-cit-0023","doi-asserted-by":"crossref","first-page":"R178","DOI":"10.1186\/ar4367","article-title":"Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis","volume":"15","author":"Munter","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/1756-185X.13061-BIB0024|apl13061-cit-0024","doi-asserted-by":"crossref","first-page":"20069","DOI":"10.1074\/jbc.M907604199","article-title":"Evidence Linking Chondrocyte Lipid Peroxidation to Cartilage Matrix Protein Degradation possible role in cartilage aging and the pathogenesis of osteoarthritis","volume":"275","author":"Tiku","year":"2000","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0025|apl13061-cit-0025","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1096\/fj.201600600R","article-title":"Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis","volume":"31","author":"Farnaghi","year":"2017","journal-title":"FASEB J"},{"key":"10.1111\/1756-185X.13061-BIB0026|apl13061-cit-0026","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/BOR.0b013e32833bfb4b","article-title":"Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome","volume":"22","author":"Katz","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"10.1111\/1756-185X.13061-BIB0027|apl13061-cit-0027","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1136\/ard.2005.039263","article-title":"Is progressive osteoarthritis an atheromatous vascular disease?","volume":"64","author":"Conaghan","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/1756-185X.13061-BIB0028|apl13061-cit-0028","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.joca.2006.09.008","article-title":"Arterial stiffness and hand osteoarthritis: a novel relationship?","volume":"15","author":"Saleh","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/1756-185X.13061-BIB0029|apl13061-cit-0029","doi-asserted-by":"crossref","first-page":"33053","DOI":"10.1074\/jbc.M005438200","article-title":"Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1","volume":"275","author":"Wang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0030|apl13061-cit-0030","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/cbf.2903","article-title":"Different responses of fluvastatin to cholesterol-induced oxidative modifications in rabbits: evidence for preventive effect against DNA damage","volume":"31","author":"Sevin","year":"2013","journal-title":"Cell Biochem Funct"},{"key":"10.1111\/1756-185X.13061-BIB0031|apl13061-cit-0031","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/01.ATV.13.9.1368","article-title":"Influx, efflux, and accumulation of LDL in normal arterial areas and atherosclerotic lesions of white Carneau pigeons with naturally occurring and cholesterol-aggravated aortic atherosclerosis","volume":"13","author":"Schwenke","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1111\/1756-185X.13061-BIB0032|apl13061-cit-0032","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1152\/physrev.00022.2005","article-title":"Mechanisms for cellular cholesterol transport: defects and human disease","volume":"86","author":"Ikonen","year":"2006","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0033|apl13061-cit-0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(01)00713-4","article-title":"Cellular cholesterol flux studies: methodological considerations","volume":"163","author":"Rothblat","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1111\/1756-185X.13061-BIB0034|apl13061-cit-0034","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1191\/1358863x05vm593ra","article-title":"ABCA1 and atherosclerosis","volume":"10","author":"Soumian","year":"2005","journal-title":"Vasc Med"},{"key":"10.1111\/1756-185X.13061-BIB0035|apl13061-cit-0035","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev.biochem.68.1.523","article-title":"Charting the fate of the \u201cgood cholesterol\u201d: identification and characterization of the high-density lipoprotein receptor SR-BI","volume":"68","author":"Krieger","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"10.1111\/1756-185X.13061-BIB0036|apl13061-cit-0036","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cardiores.2006.08.024","article-title":"Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors","volume":"72","author":"Marcil","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0037|apl13061-cit-0037","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0021-9150(02)00311-8","article-title":"Scavenger receptor BI (SR-BI) mediates a higher selective cholesteryl ester uptake from LpA-I compared with LpA-I:A-II lipoprotein particles","volume":"166","author":"Rinninger","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1111\/1756-185X.13061-BIB0038|apl13061-cit-0038","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1074\/jbc.M510261200","article-title":"SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux","volume":"281","author":"Pagler","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0039|apl13061-cit-0039","doi-asserted-by":"crossref","first-page":"23699","DOI":"10.1074\/jbc.M211233200","article-title":"Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver","volume":"278","author":"Eck","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0040|apl13061-cit-0040","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1194\/jlr.P024810","article-title":"Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis","volume":"53","author":"Adorni","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1111\/1756-185X.13061-BIB0041|apl13061-cit-0041","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/cbf.1680","article-title":"SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells","volume":"28","author":"Truong","year":"2010","journal-title":"Cell Biochem Funct"},{"key":"10.1111\/1756-185X.13061-BIB0042|apl13061-cit-0042","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/hep.25919","article-title":"Liver X receptor beta and peroxisome proliferator-activated receptor delta regulate cholesterol transport in murine cholangiocytes","volume":"56","author":"Xia","year":"2012","journal-title":"Hepatology"},{"key":"10.1111\/1756-185X.13061-BIB0043|apl13061-cit-0043","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.ATV.0000015598.86369.04","article-title":"Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis","volume":"22","author":"Barbier","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0044|apl13061-cit-0044","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbrc.2012.04.022","article-title":"ABCA1 upregulating apolipoproein M expression mediates via the RXR\/LXR pathway in HepG2 cells","volume":"421","author":"Di","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/1756-185X.13061-BIB0045|apl13061-cit-0045","doi-asserted-by":"crossref","first-page":"20117","DOI":"10.1074\/jbc.M111.235846","article-title":"Liver X receptor beta (LXRbeta) interacts directly with ATP-binding cassette A1 (ABCA1) to promote high density lipoprotein formation during acute cholesterol accumulation","volume":"286","author":"Hozoji-Inada","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0046|apl13061-cit-0046","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1194\/jlr.M800657-JLR200","article-title":"LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner","volume":"50","author":"Ouvrier","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1111\/1756-185X.13061-BIB0047|apl13061-cit-0047","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1161\/ATVBAHA.108.175042","article-title":"Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages","volume":"28","author":"Bultel","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/1756-185X.13061-BIB0048|apl13061-cit-0048","doi-asserted-by":"crossref","first-page":"e0122904","DOI":"10.1371\/journal.pone.0122904","article-title":"Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties","volume":"10","author":"Seny","year":"2015","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0049|apl13061-cit-0049","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/art.39337","article-title":"Regulation of cholesterol homeostasis by hedgehog signaling in osteoarthritic cartilage","volume":"68","author":"Ali","year":"2016","journal-title":"Arthritis Rheum"},{"key":"10.1111\/1756-185X.13061-BIB0050|apl13061-cit-0050","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13075-015-0556-y","article-title":"MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes","volume":"17","author":"Kostopoulou","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/1756-185X.13061-BIB0051|apl13061-cit-0051","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/rheumatology\/kem191","article-title":"Vascular pathology and osteoarthritis","volume":"46","author":"Findlay","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1111\/1756-185X.13061-BIB0052|apl13061-cit-0052","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/1756-185X.13061-BIB0053|apl13061-cit-0053","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/annrheumdis-2013-204494","article-title":"Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis","volume":"74","author":"Jin","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/1756-185X.13061-BIB0054|apl13061-cit-0054","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2006.10.010","article-title":"Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis","volume":"15","author":"Pearle","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/1756-185X.13061-BIB0055|apl13061-cit-0055","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00011-009-0060-4","article-title":"The major inflammatory mediator interleukin-6 and obesity","volume":"58","author":"Eder","year":"2009","journal-title":"Inflamm Res"},{"key":"10.1111\/1756-185X.13061-BIB0056|apl13061-cit-0056","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1194\/jlr.M006486","article-title":"Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol","volume":"51","author":"Zhu","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1111\/1756-185X.13061-BIB0057|apl13061-cit-0057","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/01.ATV.4.4.341","article-title":"Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque","volume":"4","author":"Faggiotto","year":"1984","journal-title":"Arteriosclerosis"},{"key":"10.1111\/1756-185X.13061-BIB0058|apl13061-cit-0058","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/01.ATV.4.4.323","article-title":"Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation","volume":"4","author":"Faggiotto","year":"1984","journal-title":"Arteriosclerosis"},{"key":"10.1111\/1756-185X.13061-BIB0059|apl13061-cit-0059","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/01.ATV.13.2.197","article-title":"An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium","volume":"13","author":"Li","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1111\/1756-185X.13061-BIB0060|apl13061-cit-0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00424-009-0724-5","article-title":"Mitochondrial function as a determinant of life span","volume":"459","author":"Lanza","year":"2010","journal-title":"Pfl\u00fcgers Archiv - Eur J Physiol"},{"key":"10.1111\/1756-185X.13061-BIB0061|apl13061-cit-0061","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1111\/1756-185X.13061-BIB0062|apl13061-cit-0062","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000083440","article-title":"Mitochondrial dysfunction as an initiating event in atherogenesis: a plausible hypothesis","volume":"103","author":"Puddu","year":"2005","journal-title":"Cardiology"},{"key":"10.1111\/1756-185X.13061-BIB0063|apl13061-cit-0063","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-94-007-2869-1_14","article-title":"Mitochondria and aging","volume":"942","author":"Lee","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1111\/1756-185X.13061-BIB0064|apl13061-cit-0064","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1042\/bj2890703","article-title":"Cholesterol increase in mitochondria: its effect on inner-membrane functions, submitochondrial localization and ultrastructural morphology","volume":"289","author":"Echegoyen","year":"1993","journal-title":"Biochem J"},{"key":"10.1111\/1756-185X.13061-BIB0065|apl13061-cit-0065","doi-asserted-by":"crossref","first-page":"H254","DOI":"10.1152\/ajpheart.1982.242.2.H254","article-title":"Mitochondrial cholesterol content and membrane properties in porcine myocardial ischemia","volume":"242","author":"Rouslin","year":"1982","journal-title":"Am J Physiol-Heart Circul Physiol"},{"key":"10.1111\/1756-185X.13061-BIB0066|apl13061-cit-0066","doi-asserted-by":"crossref","first-page":"11731","DOI":"10.1074\/jbc.M412898200","article-title":"Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function","volume":"280","author":"Yu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0067|apl13061-cit-0067","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/B978-0-12-571805-9.50009-9","article-title":"The physical state of phospholipids and cholesterol in monolayers, bilayers, and membranes","volume":"1972","author":"Phillips","year":"1972","journal-title":"Progress Surface Membrane Sci"},{"key":"10.1111\/1756-185X.13061-BIB0068|apl13061-cit-0068","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbalip.2005.01.004","article-title":"Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells","volume":"1733","author":"Hall","year":"2005","journal-title":"Biochimica et Biophysica Acta (BBA)-Molec Cell Biol Lipids"},{"key":"10.1111\/1756-185X.13061-BIB0069|apl13061-cit-0069","doi-asserted-by":"crossref","first-page":"22183","DOI":"10.1074\/jbc.R300003200","article-title":"StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism","volume":"278","author":"Soccio","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0070|apl13061-cit-0070","first-page":"3197","article-title":"Role of lipid transfer proteins in the abnormal lipid content of Morris hepatoma mitochondria and microsomes","volume":"43","author":"Crain","year":"1983","journal-title":"Cancer Res"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0071|apl13061-cit-0071","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0005-2736(75)90063-2","article-title":"Effect of cholesterol content on some physical and functional properties of mitochondria isolated from adult rat liver, fetal liver, cholesterol-enriched liver and hepatomas AH-130, 3924A and 5123","volume":"413","author":"Feo","year":"1975","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"key":"10.1111\/1756-185X.13061-BIB0072|apl13061-cit-0072","doi-asserted-by":"crossref","first-page":"33928","DOI":"10.1074\/jbc.M210943200","article-title":"Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity","volume":"278","author":"Colell","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0073|apl13061-cit-0073","doi-asserted-by":"crossref","first-page":"42468","DOI":"10.1074\/jbc.M101419200","article-title":"Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway","volume":"276","author":"Yao","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/1756-185X.13061-BIB0074|apl13061-cit-0074","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1529\/biophysj.106.097923","article-title":"Evidence of cholesterol accumulated in high curvature regions: implication to the curvature elastic energy for lipid mixtures","volume":"92","author":"Wang","year":"2007","journal-title":"Biophys J"},{"key":"10.1111\/1756-185X.13061-BIB0075|apl13061-cit-0075","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jnutbio.2009.01.001","article-title":"Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases","volume":"20","author":"Lordan","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1111\/1756-185X.13061-BIB0076|apl13061-cit-0076","doi-asserted-by":"crossref","first-page":"e65810","DOI":"10.1371\/journal.pone.0065810","article-title":"Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves","volume":"8","author":"Lehti","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/1756-185X.13061-BIB0077|apl13061-cit-0077","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1096\/fj.04-2095fje","article-title":"Oxidative stress in atherosclerosis-prone mouse is due to low antioxidant capacity of mitochondria","volume":"19","author":"Oliveira","year":"2005","journal-title":"FASEB J"},{"key":"10.1111\/1756-185X.13061-BIB0078|apl13061-cit-0078","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2004.12.041","article-title":"Reactive oxygen species promote TNF\u03b1-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases","volume":"120","author":"Kamata","year":"2005","journal-title":"Cell"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0079|apl13061-cit-0079","first-page":"25","article-title":"Mitochondrial medicine-molecular pathology of defective oxidative phosphorylation","volume":"31","author":"Fosslien","year":"2001","journal-title":"Ann Clin Lab Sci"},{"key":"10.1111\/1756-185X.13061-BIB0080|apl13061-cit-0080","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.joca.2005.08.009","article-title":"Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint","volume":"14","author":"Ostalowska","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1111\/1756-185X.13061-BIB0081|apl13061-cit-0081","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/art.20149","article-title":"Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs","volume":"50","author":"Johnson","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1111\/1756-185X.13061-BIB0082|apl13061-cit-0082","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","article-title":"Reactive oxygen species and superoxide dismutases: role in joint diseases","volume":"74","author":"Afonso","year":"2007","journal-title":"Joint Bone Spine"},{"key":"10.1111\/1756-185X.13061-BIB0083|apl13061-cit-0083","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1002\/art.21387","article-title":"Extracellular superoxide dismutase and oxidant damage in osteoarthritis","volume":"52","author":"Regan","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1111\/1756-185X.13061-BIB0084|apl13061-cit-0084","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/annrheumdis-2011-200092","article-title":"Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study","volume":"71","author":"Clockaerts","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1111\/1756-185X.13061-BIB0085|apl13061-cit-0085","first-page":"1653","article-title":"Progress of research in osteoarthritis. The anti-inflammatory effects of intra-articular injected statin on experimental osteoarthritis","volume":"19","author":"Akasaki","year":"2009","journal-title":"Clin Calcium"},{"key":"10.1111\/1756-185X.13061-BIB0086|apl13061-cit-0086","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joca.2008.06.012","article-title":"Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation","volume":"17","author":"Akasaki","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1111\/1756-185X.13061-BIB0087|apl13061-cit-0087","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jor.20953","article-title":"Protective effect of atorvastatin in cultured osteoarthritic chondrocytes","volume":"28","author":"Simopoulou","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1111\/1756-185X.13061-BIB0088|apl13061-cit-0088","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s00776-003-0724-9","article-title":"Statin stimulates bone morphogenetic protein-2, aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes","volume":"8","author":"Hatano","year":"2003","journal-title":"J Orthop Sci"},{"key":"10.1111\/1756-185X.13061-BIB0089|apl13061-cit-0089","doi-asserted-by":"crossref","first-page":"990","DOI":"10.18632\/aging.100213","article-title":"Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)","volume":"2","author":"Yudoh","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"10.1111\/1756-185X.13061-BIB0090|apl13061-cit-0090","first-page":"79","article-title":"Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"27","author":"Oliviero","year":"2009","journal-title":"Clin Exp Rheumatol"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/1756-185X.13061\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T12:41:33Z","timestamp":1719146493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":90,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13061","archive":["Portico"],"relation":{},"ISSN":["1756-1841"],"issn-type":[{"value":"1756-1841","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}