{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:44:31Z","timestamp":1694465071316},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18200044"],"award-info":[{"award-number":["18200044"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["21500676"],"award-info":[{"award-number":["21500676"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to elucidate the prevalence of radiographic knee chondrocalcinosis (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) and to clarify whether <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> is correlated with self\u2010reported knee symptoms and a serum catabolic biomarker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1278 volunteers participated. Plain radiographs of both knees were obtained. Identification of a linear calcification in the knee joint space was defined as <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>. Patients with a Kellgren\u2010Lawrence grade of 2 or more were considered to have knee osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>). Symptoms were evaluated using the Knee injury and Osteoarthritis Outcome Score (<jats:styled-content style=\"fixed-case\">KOOS<\/jats:styled-content>) Pain scale, and serum matrix metalloproteinase\u20103 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103) concentration was determined. Multiple regression analysis was conducted to determine whether <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> was correlated with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">KOOS<\/jats:styled-content> Pain scale and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight subjects were found to have <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> (2.2%), and 389 had <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> (30.4%). <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> was correlated with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> (odds ratio: 5.797; <jats:italic>P<\/jats:italic> = 0.006). Additionally, <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> was correlated with <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 concentration (B = 11.415, \u03b2 = 0.059, <jats:italic>P<\/jats:italic> = 0.014), but not with <jats:styled-content style=\"fixed-case\">KOOS<\/jats:styled-content> Pain scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> was low in the Japanese population evaluated in this study. While <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> was not correlated with self\u2010reported knee symptoms, it was positively correlated with serum <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 concentration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13067","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T12:17:23Z","timestamp":1490357843000},"page":"2011-2018","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low prevalence of knee chondrocalcinosis and its catabolic association with serum matrix metalloproteinase 3: A rural Japanese population study"],"prefix":"10.1111","volume":"21","author":[{"given":"Daisuke","family":"Chiba","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ippei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Nakaji","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hirosaki University Graduate School of Medicine Hirosaki Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150508"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.4.371"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.7.520"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.2.97"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.04.022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.04.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.22.3.142"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196708102770603"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3447-z"},{"key":"e_1_2_7_11_1","first-page":"1241","article-title":"The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study","volume":"16","author":"Felson DT","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.6.513"},{"key":"e_1_2_7_13_1","first-page":"981","article-title":"Prevalence of chondrocalcinosis in Italian subjects from northeastern Italy. 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