{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:00:28Z","timestamp":1784570428293,"version":"3.55.0"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To critically appraise and evaluate the evidence for effectiveness of curcuminoids in the treatment of osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>) in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted electronic searches in Medline, Embase,<jats:styled-content style=\"fixed-case\">AMED<\/jats:styled-content>, Cinahl and the Cochrane library. We included randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) that investigated the effectiveness of orally\u2010administered curcuminoids in<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>in adults, and assessed risk of bias using the Cochrane risk of bias criteria. We used a random\u2010effect model for meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included seven studies with a total of 797 participants with primarily knee<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>. All studies were conducted in Asia. The overall risk of bias was moderate. Compared with placebo, curcuminoids significantly reduced knee pain (visual analogue scale): (standardized mean difference: \u22123.45; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22125.52 to \u22121.38;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a095%<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and improved quality of life (Lequesne pain\u2010function index): (mean difference: \u22122.69; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22123.48 to \u22121.90;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.00001). There were significantly fewer effects on pain relief, knee stiffness and physical function with curcuminoids compared with ibuprofen. Significant improvements in Western Ontario and McMaster Universities Arthritis Index total scores, with significant reductions in the use of rescue medication were also observed with curcuminoids. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Curcuminoids may have some beneficial effects on knee pain and quality of life in patients with knee<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>. However, they are less effective at relieving pain compared with ibuprofen. Curcuminoids appear safe on the short\u2010term, and may reduce the need for rescue medication. Published<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s vary in reporting quality, are characterized by small sample sizes, and have all been conducted in Asia. Further clinical trials are therefore warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13069","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T06:48:44Z","timestamp":1493880524000},"page":"420-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta\u2010analysis of randomized clinical trials"],"prefix":"10.1111","volume":"20","author":[{"given":"Igho J.","family":"Onakpoya","sequence":"first","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences Centre for Evidence\u2010Based Medicine University of Oxford Radcliffe Observatory Quarter Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences Centre for Evidence\u2010Based Medicine University of Oxford Radcliffe Observatory Quarter Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Perera","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences Centre for Evidence\u2010Based Medicine University of Oxford Radcliffe Observatory Quarter Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences Centre for Evidence\u2010Based Medicine University of Oxford Radcliffe Observatory Quarter Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"22","article-title":"Obesity: risk factor and predictor of osteoarthritis [in Croatian]","volume":"131","author":"Grazio S","year":"2009","journal-title":"Lijec Vjesn"},{"key":"e_1_2_10_3_1","unstructured":"Centers for Disease Control and Prevention(2015)Osteoarthritis. 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