{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:25:38Z","timestamp":1782523538602,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2012R1A1A1002580"],"award-info":[{"award-number":["2012R1A1A1002580"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Interleukin (IL<\/jats:styled-content>)\u201032 is known to act as a proinflammatory cytokine and is likely involved in several chronic inflammatory diseases. The aims of this study were to investigate whether serum IL<\/jats:styled-content>\u201032 levels are elevated in patients with Beh\u00e7et's disease (BD<\/jats:styled-content>) and to identify the correlation between IL<\/jats:styled-content>\u201032 levels and disease activity.<\/jats:p><\/jats:sec>Methods<\/jats:title>We enrolled 50 patients with BD<\/jats:styled-content> and 35 healthy controls. Serum IL<\/jats:styled-content>\u201032 levels were measured using an enzyme\u2010linked immunosorbent assay. Serum levels of IL<\/jats:styled-content>\u201012p70, IL<\/jats:styled-content>\u201017A, IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u20108 were measured using a multiplex assay. BD<\/jats:styled-content> disease activity was determined using the Beh\u00e7et's Disease Current Activity Form (BDCAF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Serum IL<\/jats:styled-content>\u201032 levels were significantly higher in patients with BD<\/jats:styled-content> (median [interquartile ranges], 0.4 [0.1\u2013736.2] pg\/mL<\/jats:styled-content>) than in healthy controls (0.1 [0.1\u201314.7] pg\/mL<\/jats:styled-content>, P<\/jats:italic> = 0.041). When patients with BD<\/jats:styled-content> were divided into active (patient index score \u2265 2 or transformed index score \u2265 5 in the BDCAF<\/jats:styled-content>) and inactive groups, IL<\/jats:styled-content>\u201032 levels tended to be higher in patients with active BD<\/jats:styled-content>, although this observation was statistically insignificant. Serum levels of IL<\/jats:styled-content>\u201012p70, IL<\/jats:styled-content>\u201017A, IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u20108 did not differ between active and inactive groups. There was a weak positive correlation between serum IL<\/jats:styled-content>\u201032 levels and BDCAF<\/jats:styled-content> scores (R<\/jats:italic> = 0.301, P<\/jats:italic> = 0.033). BD<\/jats:styled-content> patients with recent arthralgia exhibited higher IL<\/jats:styled-content>\u201032 levels than did those without (P<\/jats:italic> < 0.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings suggest that IL<\/jats:styled-content>\u201032 may play a minor role in the pathogenesis of BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13072","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T18:40:20Z","timestamp":1491417620000},"page":"2167-2174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased serum interleukin\u201032 levels in patients with Beh\u00e7et's disease"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-9523","authenticated-orcid":false,"given":"You\u2010Jung","family":"Ha","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Seoul National University Bundang Hospital Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Su","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine National Health Insurance Service Ilsan Hospital Goyang\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010il","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Dankook University College of Medicine Cheonan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Kon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-3341","authenticated-orcid":false,"given":"Sang\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.02.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0502-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02184.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0029-8"},{"key":"e_1_2_8_7_1","first-page":"6","article-title":"Serum IL\u201033 levels and skin mRNA expression in Beh\u00e7et's disease","volume":"31","author":"Hamzaoui K","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.148.2.597"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8413768"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712381105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03025.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-015-0083-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.12.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508237102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003996"},{"key":"e_1_2_8_16_1","first-page":"289","article-title":"Interleukin\u201032, CCL2, PF4F1 and GFD10 are the only cytokine\/chemokine genes differentially expressed by in\u00a0vitro cultured rheumatoid and osteoarthritis fibroblast\u2010like synoviocytes","volume":"16","author":"Cagnard N","year":"2005","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6036-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes163"},{"key":"e_1_2_8_19_1","first-page":"73","article-title":"Clinical significance of interleukin\u201032 expression in patients with rheumatoid arthritis","volume":"31","author":"Gui M","year":"2013","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-013-1036-5"},{"key":"e_1_2_8_21_1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg453"},{"key":"e_1_2_8_24_1","first-page":"2151","article-title":"High mobility group box 1 serum levels are increased in Beh\u00e7et's disease, but not associated with disease activity or disease manifestations","volume":"54","author":"Souza AW","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.30.5.714"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03439.x"},{"key":"e_1_2_8_27_1","first-page":"865","article-title":"IL\u201032 is increased along with tryptase in lesional psoriatic skin and is up\u2010regulated by substance P in human mast cells","volume":"20","author":"Kempuraj D","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9837-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002306"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.4268"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21772"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.01.013"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139196"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511233103"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T23:30:03Z","timestamp":1694734203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/1756-185X.13072"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13072","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]},"assertion":[{"value":"2017-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}