{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:24:08Z","timestamp":1785277448489,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Medial meniscus tear has been proposed as a potential etiology of spontaneous osteonecrosis of the knee (<jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content>). Disruption of collagen fibers within the meniscus causes meniscal extrusion, which results in alteration in load distribution in the knee. Our purpose was to determine whether the extent of medial meniscus extrusion correlates with the severity of <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> in the medial femoral condyle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Radiological stage of <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> and femorotibial angle (<jats:styled-content style=\"fixed-case\">FTA<\/jats:styled-content>) were determined on knee radiographs. Ellipsoid volume of <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> lesion and meniscal pathology (degeneration, tear and extrusion) were evaluated by magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the 18 knees with <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> in the present study showed substantial extrusion (\u2265 3 mm) and degeneration of the medial meniscus. The extent of meniscal extrusion and <jats:styled-content style=\"fixed-case\">FTA<\/jats:styled-content> were strongly associated with the stage and volume of the <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> lesion. Multiple linear regression analysis revealed that medial meniscus extrusion and <jats:styled-content style=\"fixed-case\">FTA<\/jats:styled-content> were useful predictors of the volume of the <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was high association of medial meniscus extrusion and <jats:styled-content style=\"fixed-case\">FTA<\/jats:styled-content> with the radiological stage and volume of the <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> lesion. Increased loading in the medial femoral condyle with greater extrusion of medial meniscus and varus alignment may contribute to expansion and secondary osteoarthritic changes of a <jats:styled-content style=\"fixed-case\">SONK<\/jats:styled-content> lesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13074","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T18:38:54Z","timestamp":1491417534000},"page":"2104-2111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Association between medial meniscus extrusion and spontaneous osteonecrosis of the knee"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-9300","authenticated-orcid":false,"given":"Tadashi","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Kobe City Medical Center General Hospital Kobe 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