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The clinical and laboratory data were extracted, and a meta\u2010analysis was performed to evaluate the risk factors for CSI in RA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies involving a total of 2750 cases with RA and 733 CSI (26.65%) were eligible and included in this meta\u2010analysis. The results showed that risk factors for CSI were female (odds ratio [OR] = 1.37, 95% confidence interval [CI]: 1.079\u20131.74), positive rheumatoid factor (RF) (OR = 1.351, 95% CI: 1.084\u20131.683), long\u2010term corticosteroids treatment (OR = 2.208, 95% CI: 1.732\u20132.815), erosion in hands or feet (OR = 2.559, 95% CI: 1.985\u20133.299), age (weighted mean difference [WMD] = \u22122.464 years, 95% CI: \u22123.688 to \u22121.240), RA duration (WMD = 1.495 years, 95% CI: 0.870\u20132.121), erythrocyte sedimentation rate (ESR) level (standard mean difference [SMD] = 0.288, 95% CI: 0.161\u20130.41), C\u2010reactive protein (CRP) level (SMD = 0.288, 95% CI: 0.161\u20130.415), Disease Activity Score of 28 joints (SMD = 0.5, 95% CI: 0.303\u20130.697).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The significant risk factors for CSI in RA were female gender, positive RF, long\u2010term corticosteroids treatment, peripheral joints erosions, younger age, long RA duration, markers of higher disease activity (ESR, CRP and Disease Activity Score).<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13096","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T11:23:55Z","timestamp":1495193035000},"page":"541-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cervical spine involvement risk factors in rheumatoid arthritis: a meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Shuai","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology West China Hospital Sichuan University Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangdong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology West China Hospital Sichuan University Sichuan 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