{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:34:59Z","timestamp":1780670099029,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Olive oil was used in the past as a remedy for many diseases due to its unlimited benefits in health. This study was carried out to assess the analgesic, anti\u2010pyretic and anti\u2010inflammatory activities of extra virgin olive oil (<jats:styled-content style=\"fixed-case\">EVOO<\/jats:styled-content>) at a dose of 8\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/kg body weight and to compare it with ibuprofen (<jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content>) as an individual drug therapy and in combination with two different doses of <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content> (therapeutic dose 100\u00a0mg\/kg and low dose 40\u00a0mg\/kg), on different animal models in albino mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 132 adult healthy male Swiss albino mice were used in this study. The analgesic effect was assessed using acetic acid\u2010induced writhing test. The antipyretic effect was evaluated by brewer's yeast\u2010induced pyrexia, while the anti\u2010inflammatory activity was assessed by two different models; the carrageenan\u2010induced paw edema and the carrageenan\u2010induced peritonitis in which the levels of total leukocyte count (<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>), neutrophil count, prostaglandin E2 (<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2) and interferon gamma (<jats:styled-content style=\"fixed-case\">INF<\/jats:styled-content>\u2010\u03b3) were measured in the peritoneal exudates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed significant protection in all the treated groups; however, the combination of <jats:styled-content style=\"fixed-case\">EVOO<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content> at its therapeutic dose showed superiority over the two compounds when used separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using <jats:styled-content style=\"fixed-case\">EVOO<\/jats:styled-content> with the therapeutic dose of <jats:styled-content style=\"fixed-case\">IBU<\/jats:styled-content> showed synergistic effect in controlling the cardinal signs of acute inflammation rather than using non\u2010steroidal anti\u2010inflammatory drugs alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13105","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T02:46:41Z","timestamp":1496890001000},"page":"1326-1336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synergistic analgesic, anti\u2010pyretic and anti\u2010inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice"],"prefix":"10.1111","volume":"20","author":[{"given":"Walla'a 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