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This study assessed factors associated with non\u2010adherence to treatment in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> who visited in the outpatient clinic of Connective Tissue Diseases Research Center in Tabriz University of Medical Sciences were included in the study. Adherence to treatment was evaluated by the consideration of medication compliance and appointment\u2010keeping behavior. The relationships between adherence rate and six groups of variables were examined. A regression analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 137 patients (84 male and 53 female) were included. Totally, 50.7% of the patients were non\u2010adherent to treatment. Side effects of medications and the high cost of treatment were the most frequent causes of non\u2010adherence. Non\u2010adherence was significantly more common in men, patients with low income, patients who were unaware of the disease complications, employed persons, and in patients who were on treatment with non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010adherence is common in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Male sex, low income, low knowledge about the disease, being employed and being on treatment with <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s are the main risk factors for non\u2010adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13109","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T08:28:41Z","timestamp":1497860921000},"page":"2158-2166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adherence to treatment in patients with Beh\u00e7et's disease"],"prefix":"10.1111","volume":"21","author":[{"given":"Alireza","family":"Khabbazi","sequence":"first","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Karkon Shayan","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Ghojazadeh","sequence":"additional","affiliation":[{"name":"Department of Physiology Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadise","family":"Kavandi","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrzad","family":"Hajialiloo","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Esalat Manesh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kashan University of Medical Sciences Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sousan","family":"Kolahi","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8077.2007.00295.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1235-7"},{"key":"e_1_2_7_4_1","first-page":"233","article-title":"Beh\u00e7et's Disease","volume":"43","author":"Davatchi F","year":"2005","journal-title":"Acta Medica Iranica"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.8.589"},{"key":"e_1_2_7_6_1","article-title":"Demographic and clinical features of Beh\u00e7et's disease in Azerbaijan","author":"Khabbazi A","year":"2014","journal-title":"Int J Rheum Dis"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990040453009"},{"key":"e_1_2_7_8_1","first-page":"14","article-title":"Noncompliance: a $100 billion problem","volume":"5","author":"Lewis A","year":"1997","journal-title":"Remington Rep"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/58.12.1126"},{"key":"e_1_2_7_10_1","first-page":"266","article-title":"Compliance in schizophrenia: predictive factors, therapeutical considerations and research implications","volume":"28","author":"Misdrahi D","year":"2002","journal-title":"Encephale"},{"issue":"9","key":"e_1_2_7_11_1","first-page":"67","article-title":"Medication non\u2010adherence: Part II\u2010a pilot study in patients with congestive heart failure","volume":"11","author":"Rodgers PT","year":"1998","journal-title":"Manag Care Interface"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200012)13:6<406::AID-ART11>3.0.CO;2-2"},{"key":"e_1_2_7_13_1","first-page":"50","article-title":"Reduced burden of disease and improved outcome of patients with rheumatoid factor positive rheumatoid arthritis compared with dropouts. 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