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The four patients had various clinical presentations: one had an initial diagnosis of seropositive rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) with involvement of the sacroiliac joints (similar to previous reports of the association of two diseases); one had a clinical picture of reactive arthritis following an episode of an <jats:italic>Escherichia coli<\/jats:italic> positive urinary tract infection; and two had asymmetrical sacroiliitis (<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>), but no evidence of peripheral joint involvement (never reported before). In all cases, high titers of anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> antibodies were found. We present a comparison of the clinical manifestations, radiographic features and treatment regimens of these cases. Our report supports previous literature data of possible overlap existing between <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and SpA, but also presents for the first time the association of high titers of anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> antibodies with <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content> and reactive arthritis in patients with no peripheral small joint involvement.<\/jats:p>","DOI":"10.1111\/1756-185x.13113","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T01:16:44Z","timestamp":1496798204000},"page":"315-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Strongly positive anti\u2010<scp>CCP<\/scp> antibodies in patients with sacroiliitis or reactive arthritis post\u2010<i>E.\u00a0coli<\/i> infection: A mini case\u2010series based review"],"prefix":"10.1111","volume":"21","author":[{"given":"Miljyot","family":"Singh Sangha","sequence":"first","affiliation":[{"name":"Medical School University College London Hospitals NHS Foundation Trust London UK"},{"name":"Department of Rheumatology University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew Liam","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-4113","authenticated-orcid":false,"given":"Coziana","family":"Ciurtin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University College London Hospitals NHS Foundation Trust London 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