{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:43:04Z","timestamp":1761896584308,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Celgene Pty. Ltd."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the treatment regimens, duration of therapy and reasons for disease\u2010modifying antirheumatic drug (<jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>) cessation in a large psoriatic arthritis (PsA) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective non\u2010interventional multi\u2010centre study using Audit4 electronic medical records, with de\u2010identified, routinely collected clinical data from rheumatology practices in the <jats:styled-content style=\"fixed-case\">OPAL<\/jats:styled-content> consortium (Optimising Patient outcomes in Australian rheumatoLogy) during November 2015. Baseline characteristics, type and duration of conventional and biologic <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content>, respectively), disease activity (Disease Activity Score of 28 joints C\u2010reactive protein [<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>]), and reasons for treatment cessation were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3422 rheumatologist\u2010diagnosed PsA patients were included: 60% female, mean age 54 years and disease duration 10 years. Of patients with treatment recorded (<jats:italic>n<\/jats:italic> = 2948), 46% were on <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content> monotherapy, 19% <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> monotherapy, 13% combination <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content>s, 11% combination <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content>s and 10% no <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>s. Of those with <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> results (<jats:italic>n<\/jats:italic> = 494), the highest mean <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was 3.32 on combination <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content>s, and the lowest was 2.19 on <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> monotherapy. Median duration on <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content> monotherapy was 33.5 months (<jats:italic>n<\/jats:italic> = 2232), on <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> monotherapy 110.1 months (<jats:italic>n<\/jats:italic> = 751), on combination <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content>s 68.5 months (<jats:italic>n<\/jats:italic> = 559). The most common reasons for cessation of <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content> monotherapy was adverse reactions (41%), for <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> monotherapy lack of efficacy (26%), and for combination <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content>s treatment completed or no longer required (37%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most PsA patients were prescribed <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content> therapies with a large proportion receiving <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content>s. Patients on combination <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content> therapies had the highest <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> results. Adverse reactions were the most common reason for cessation of <jats:styled-content style=\"fixed-case\">cDMARD<\/jats:styled-content> monotherapy, whereas for <jats:styled-content style=\"fixed-case\">bDMARD<\/jats:styled-content> monotherapy it was lack of efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13127","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:20:55Z","timestamp":1500625255000},"page":"510-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Psoriatic arthritis treatment regimens, therapy duration and reasons for cessation in the biologics era: a multi\u2010centre Australian study"],"prefix":"10.1111","volume":"21","author":[{"given":"Kathleen","family":"Tymms","sequence":"first","affiliation":[{"name":"Canberra Rheumatology Canberra Australian Capital Territory Australia"},{"name":"Rheumatology Department Canberra Hospital Canberra Australian 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