{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:51:00Z","timestamp":1775915460202,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the efficacy of abatacept in patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) using magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) of bilateral hands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This prospective study included 35 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> of bilateral hands was performed at baseline and after 12\u00a0months of treatment with intravenous abatacept. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images were scored for synovitis, osteitis, erosion and joint space narrowing (<jats:styled-content style=\"fixed-case\">JSN<\/jats:styled-content>) according to the <jats:styled-content style=\"fixed-case\">RA MRI<\/jats:styled-content> Scoring System (<jats:styled-content style=\"fixed-case\">RAMRIS<\/jats:styled-content>). The primary endpoint was the change in <jats:styled-content style=\"fixed-case\">RAMRIS<\/jats:styled-content> score from baseline. Repair of erosion was defined as a negative change in the erosion score that was greater than the smallest detectable changes (<jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients completed the study. Median synovitis and osteitis scores showed statistically significant reductions at Month 12 when compared to baseline (synovitis score, \u22125.5 [<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001]; osteitis score, \u22120.5 [<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03]). However, median erosion and <jats:styled-content style=\"fixed-case\">JSN<\/jats:styled-content> scores did not significantly change. At Month 12, 83% of patients showed no progression of erosion scores and repair of erosion was observed in 11% of patients. All patients with repair of erosion achieved functional remission (Health Assessment Questionnaire\u2010Disability Index \u2264\u00a00.5). The Simplified Disease Activity Index response rate at Month 1 was identified as an independent factor predicting changes in the erosion scores at Month 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abatacept treatment reduced synovitis and osteitis scores and did not worsen erosion and <jats:styled-content style=\"fixed-case\">JSN<\/jats:styled-content> scores at Month 12. Over 10% of patients experienced repair of erosion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13135","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T08:20:10Z","timestamp":1500625210000},"page":"1678-1685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-4533","authenticated-orcid":false,"given":"Yuji","family":"Kukida","sequence":"first","affiliation":[{"name":"Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Inflammation and Immunology Graduate School of 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