{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:17:52Z","timestamp":1784546272234,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ICMR-INSERM"},{"name":"INSERM UMRS 940"},{"name":"Assistance Publique des H\u00f4pitaux de Paris"},{"name":"Hospital Saint Louis, Paris","award":["INDO\/FRC\/526\/2005"],"award-info":[{"award-number":["INDO\/FRC\/526\/2005"]}]},{"name":"Hospital Saint Louis, Paris","award":["50\/8\/2004\/BMS"],"award-info":[{"award-number":["50\/8\/2004\/BMS"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Rheumatoid arthritis (RA<\/jats:styled-content>) is a clinically heterogeneous chronic inflammatory disorder characterized by synovitis leading to joint destruction. Both genetic and environmental factors are involved in the pathogenesis of RA<\/jats:styled-content>. Significant dysregulation of NKG<\/jats:styled-content>2D, an activating receptor of natural killer and certain autoreactive T cells as well as its ligand major histocompatibility complex class I chain\u2013related gene A (MICA<\/jats:styled-content>) has been implicated in perpetuating the pathology of RA<\/jats:styled-content>. Since the genetic polymorphism in MICA<\/jats:styled-content><\/jats:italic> gene (MICA<\/jats:styled-content>\u2010129<\/jats:italic> met\/val polymorphism at codon 129) is known to affect its binding affinity to NKG<\/jats:styled-content>2D, we explored its influence on RA<\/jats:styled-content> susceptibility and disease severity.<\/jats:p><\/jats:sec>Methods<\/jats:title>The MICA<\/jats:styled-content>\u2010129<\/jats:italic> met\/val polymorphism was examined in 270 patients with RA<\/jats:styled-content> and 232 healthy controls by TaqMan 5\u2032\u2010nuclease assay. Serum soluble MICA<\/jats:styled-content> (sMICA<\/jats:styled-content>) was measured in a subset of 89 patients and 80 controls by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec>Results<\/jats:title>We observed that the frequency of MICA<\/jats:styled-content>\u2010129<\/jats:italic> val allele (73% vs<\/jats:italic>. 65%, P<\/jats:italic>c = 0.006, odds ratio = 1.48, 95% CI<\/jats:styled-content> = 1.12\u20131.95) was higher in patients than in controls. sMICA<\/jats:styled-content> levels were significantly higher in patients with RA<\/jats:styled-content> than in controls (P<\/jats:italic> < 0.0001). sMICA<\/jats:styled-content> levels were higher in patients with val\/val genotype than in those with met\/val or met\/met genotype (P<\/jats:italic> = 0.03). The MICA<\/jats:styled-content>\u2010129<\/jats:italic> val\/val genotype was associated with high titers of sMICA<\/jats:styled-content> in patients with deforming RA<\/jats:styled-content> phenotype (P<\/jats:italic> = 0.02), suggesting a role in determination of severity of RA.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>MICA<\/jats:styled-content>\u2010129<\/jats:italic> val\/val genotype, associated with higher levels of circulating sMICA<\/jats:styled-content>, may influence disease susceptibility and associate with increased severity of RA<\/jats:styled-content> in south Indian Tamils.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13138","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T02:17:53Z","timestamp":1501208273000},"page":"656-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of MICA\u2010129<\/i> polymorphism and circulating soluble MICA level with rheumatoid arthritis in a south Indian Tamil population"],"prefix":"10.1111","volume":"21","author":[{"given":"Christina M.","family":"Mariaselvam","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"},{"name":"INSERM, UMRS 1160 Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Boukouaci","sequence":"additional","affiliation":[{"name":"INSERM, UMRS 1160 Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Charron","sequence":"additional","affiliation":[{"name":"INSERM, UMRS 1160 Saint Louis Hospital Paris France"},{"name":"Jean Dausset Department of Immunology and Immunogenetics and LabExTransplantex Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"INSERM, UMRS 1160 Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-9565","authenticated-orcid":false,"given":"Ryad","family":"Tamouza","sequence":"additional","affiliation":[{"name":"INSERM, UMRS 1160 Saint Louis Hospital Paris France"},{"name":"Jean Dausset Department of Immunology and Immunogenetics and LabExTransplantex Saint Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-7396","authenticated-orcid":false,"given":"Durga P.","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"},{"name":"Department of Clinical Immunology Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-6031","authenticated-orcid":false,"given":"Vir S.","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.10.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301258"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080675"},{"key":"e_1_2_8_6_1","first-page":"240","article-title":"Prevalence of rheumatic diseases in a rural population in western India: a WHO\u2010ILAR COPCORD Study","volume":"49","author":"Chopra A","year":"2001","journal-title":"J Assoc Physicians India"},{"issue":"8","key":"e_1_2_8_7_1","first-page":"1420","article-title":"A comparison of the performance of different methods of disease classification for rheumatoid arthritis. 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