{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:06:41Z","timestamp":1785175601074,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20133BAB20003"],"award-info":[{"award-number":["20133BAB20003"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Previous research has shown that adiponectin (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) induces severe insulin resistance (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) and exhibits pro\u2010inflammatory effect, so it could serve as a useful risk biomarker in rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). The present study aims to evaluate the effect of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and anti\u2010arthritis in collagen\u2010induced arthritic (<jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content>) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>After immunization with bovine type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> collagen (<jats:styled-content style=\"fixed-case\">CII<\/jats:styled-content>), Wistar rats were administered with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (60\u00a0\u03bcg\/kg\/day) or saline into the ankle joint cavity of the left hind leg for 15\u00a0days. The severity of arthritis was clinically and histologically assessed. Arthritis score was recorded every other day for each paw. Paw volume was measured on alternate days to monitor the progression of the disease in the arthritic control group. Tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101, <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, insulin and fasting glucose were measured in sera. Histopathology of joint synovial tissues was also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> resulted in significantly delayed onset of arthritis as well as decreased clinical arthritis and histopathological severity scores. <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> reduced both serum fasting glucose, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. Histological analysis confirmed treatment with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> suppressed joint synovial inflammation and immunohistochemical expression of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 compared to the <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content> group. Surprisingly, adiponectin levels measured by enzyme\u2010linked immunosorbent assay in serum were significantly increased in <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content> rats compared to the normal group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adiponectin might display anti\u2010inflammatory effects. These results suggest that <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> may be a potential immunosuppressant for the treatment of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> linked to metabolic disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13141","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:25:15Z","timestamp":1501230315000},"page":"1496-1503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adiponectin exerts a potent anti\u2010arthritic effect and insulin resistance in collagen\u2010induced arthritic rats"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-082X","authenticated-orcid":false,"given":"Dongke","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Internal Clinical Medicine the first Affiliated Hospital of Nanchang University Nanchang 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