{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:57:43Z","timestamp":1769212663450,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) has been recognized as an unclassified type of vasculitis with an accompanying tendency to thrombosis. No disease\u2010specific pathology has been demonstrated so far to explain the prothrombotic state, and this predisposition is considered to be associated with endothelial activation\/dysfunction. P\u2010selectin glycoprotein ligand\u20101 (<jats:styled-content style=\"fixed-case\">PSGL<\/jats:styled-content>\u20101) variable number of tandem repeat (<jats:styled-content style=\"fixed-case\">VNTR<\/jats:styled-content>) polymorphism has an impact on the protein length, and heterozygosity affect of the <jats:styled-content style=\"fixed-case\">PSGL<\/jats:styled-content>\u20101 to P\u2010selectin interaction, which has been found to be associated with an increased risk of thrombosis in patients with antiphospholipid syndrome. We aimed to analyze the association of <jats:styled-content style=\"fixed-case\">PSGL<\/jats:styled-content>\u20101 gene polymorphism, in a group of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients with and without thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group consisted of 136 <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients (112 male, 24 female) with thrombosis, 120 <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients without thrombosis (54 male, 66 female) during at least 5\u00a0years disease course, and 190 healthy controls (103 male, 87 female) All patients fulfilled the International Study Group criteria for classification of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Genotyping for the <jats:styled-content style=\"fixed-case\">PSGL<\/jats:styled-content>\u20101 gene exon 2 <jats:styled-content style=\"fixed-case\">VNTR<\/jats:styled-content> polymorphism was carried out with the amplification of genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and running of the polymerase chain reaction product on agarose gel electrophoresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of heterozygous genotypes (<jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>) was greater in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients with thrombosis compared to <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients without thrombosis (33.1% <jats:italic>vs<\/jats:italic>. 20.8%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028, odds ratio\u00a0=\u00a01.85). However, the increased frequency of heterozygous genotypes in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients with thrombosis did not reach a statistically significant level compared to healthy controls (33.1% <jats:italic>vs<\/jats:italic>. 32.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PSGL<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">VNTR<\/jats:styled-content> polymorphism may have limited contribution to the thrombotic tendency in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13151","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T02:46:44Z","timestamp":1502765204000},"page":"2175-2179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Beh\u00e7et's disease"],"prefix":"10.1111","volume":"21","author":[{"given":"Fulya","family":"Cosan","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Faculty of Medicine Bahcesehir University Istanbul Turkey"},{"name":"Division of Rheumatology Department of Internal Medicine Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basar","family":"Oku","sequence":"additional","affiliation":[{"name":"Department of Genetics Institute for Experimental Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-6501","authenticated-orcid":false,"given":"Ozgun M.","family":"Gedar Totuk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Bahcesehir University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"Abaci","sequence":"additional","affiliation":[{"name":"Department of Genetics Institute for Experimental Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duran","family":"Ustek","sequence":"additional","affiliation":[{"name":"Department of Genetics Institute for Experimental Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhan","family":"Diz Kucukkaya","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine Istanbul Bilim University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Gul","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Faculty of Medicine Istanbul University Istanbul 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