{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:57:07Z","timestamp":1774403827119,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome (<jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The well\u2010validated and disease\u2010specific Boston Carpal Tunnel Questionnaire (<jats:styled-content style=\"fixed-case\">BCTQ<\/jats:styled-content>) was employed and its score at 4 weeks after treatment was used as the primary outcome measure. Important secondary outcomes included patient satisfaction, the change of an objective finger dexterity test and the side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients in the local steroid group and 25 patients in the wrist splinting group completed the study procedures. At 4 weeks after treatment, there was significant improvement of the <jats:styled-content style=\"fixed-case\">BTCQ<\/jats:styled-content> scores in both the steroid group and splinting group. There was improvement of the finger dexterity test only in the steroid group but not in the splinting group. However, there was no statistically significant difference in the changes of <jats:styled-content style=\"fixed-case\">BTCQ<\/jats:styled-content> scores between the two groups after treatment. Patient satisfaction score was higher in the steroid group. Patients in the steroid group took fewer painkillers after treatment. Four patients developed side effects after splinting and three after local steroid injection, which was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although local steroid injection and nocturnal wrist splinting were equally effective in the treatment of patients with <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>, only the former improved objective hand function. Local steroid injection also resulted in better patient satisfaction and less painkiller use without causing more side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13162","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T11:04:50Z","timestamp":1505300690000},"page":"102-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Local steroid injection versus wrist splinting for carpal tunnel syndrome: A randomized clinical trial"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-9390","authenticated-orcid":false,"given":"Ho","family":"So","sequence":"first","affiliation":[{"name":"Kwong Wah Hospital Tung Wah Group of Hospitals Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent C. H.","family":"Chung","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Tung Wah Group of Hospitals Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C. K.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Kwong Wah Hospital Tung Wah Group of Hospitals Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M. L.","family":"Yip","sequence":"additional","affiliation":[{"name":"Integrated Diagnostic and Medical Centre Tung Wah Group of Hospitals Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-010-9263-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.1.134"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/oeh.1998.4.2.99"},{"key":"e_1_2_7_5_1","first-page":"001554","article-title":"Local corticosteroid injection for carpal tunnel syndrome","volume":"18","author":"Marshall S","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0163-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.115337"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/153944928500500102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2005.04.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(94)90054-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-78"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00642"},{"issue":"5","key":"e_1_2_7_13_1","first-page":"342","article-title":"Evaluation of a Hong Kong Chinese version of a self\u2010administered questionnaire for assessing symptom severity and functional status of carpal tunnel syndrome: cross\u2010cultural adaptation and reliability","volume":"13","author":"Fok MW","year":"2007","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062070-00020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(94)90054-X"},{"issue":"2","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.PRS.0000101055.76543.C7","article-title":"A prospective study to assess the outcome of steroid injections and wrist splinting for the treatment of carpal tunnel syndrome","volume":"113","author":"Graham RG","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.08.022"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2006.01.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.01.005"},{"key":"e_1_2_7_20_1","unstructured":"World Health Organization(1995)Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854.WHO Geneva."},{"key":"e_1_2_7_21_1","first-page":"01552","article-title":"Surgical versus non\u2010surgical treatment for carpal tunnel syndrome","volume":"4","author":"Verdugo RJ","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.05.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38863.632789.1F"},{"key":"e_1_2_7_24_1","first-page":"03219","article-title":"Non\u2010surgical treatment (other than steroid injection) for carpal tunnel syndrome","volume":"1","author":"O'Connor D","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/art.20767","article-title":"Surgical decompression versus local steroid injection in carpal tunnel syndrome","volume":"529","author":"Ly\u2010Pen D","year":"2005","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200203000-00005"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-004-0229-0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31829b4d72"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T09:31:33Z","timestamp":1695893493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,13]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/1756-185X.13162"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13162","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,13]]},"assertion":[{"value":"2017-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}