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HUVEC<\/jats:styled-content>s were divided into four groups: ddH2<\/jats:sub>O group, ddH2<\/jats:sub>O + MSU<\/jats:styled-content> group, 1\/2 ddH2<\/jats:sub>O +1\/2 SHQ<\/jats:styled-content>\u00a0+\u00a0MSU<\/jats:styled-content> group, and SHQ<\/jats:styled-content>\u00a0+\u00a0MSU<\/jats:styled-content> group. The effects of SHQ<\/jats:styled-content> on cell viability, concentration and expression of intercellular adhesion molecule\u20101 (ICAM<\/jats:styled-content>\u20101), and MSU<\/jats:styled-content>\u2010induced release of interleukin (IL<\/jats:styled-content>)\u20101\u03b2 and IL<\/jats:styled-content>\u20106 were investigated. Additionally, cell viability and ICAM<\/jats:styled-content>\u20101 concentration and expression were detected after HUVEC<\/jats:styled-content>s were incubated with the culture supernatant of THP<\/jats:styled-content>\u20101 cells that had been treated with phorbol 12\u2010myristate 13\u2010acetate (PMA<\/jats:styled-content>), MSU<\/jats:styled-content> and SHQ<\/jats:styled-content> for 24\u00a0h.<\/jats:p><\/jats:sec>Results<\/jats:title>The viability of HUVEC<\/jats:styled-content>s was significantly decreased with increasing transfection concentrations of MSU<\/jats:styled-content>, and MSU<\/jats:styled-content> treatment resulted in a significant increase of the concentration and expression of ICAM<\/jats:styled-content>\u20101. In addition, SHQ<\/jats:styled-content> improved the MSU<\/jats:styled-content>\u2010induced decrease in cell viability and alleviated MSU<\/jats:styled-content>\u2010mediated increase in ICAM<\/jats:styled-content>\u20101 levels. Moreover, SHQ<\/jats:styled-content> decreased MSU<\/jats:styled-content>\u2010induced release of IL<\/jats:styled-content>\u20101\u03b2 and IL<\/jats:styled-content>\u20106. After HUVEC<\/jats:styled-content>s were incubated with the culture supernatant of THP<\/jats:styled-content>\u20101 cells that had been treated with PMA<\/jats:styled-content>, MSU<\/jats:styled-content> and SHQ<\/jats:styled-content> for 24\u00a0h, SHQ<\/jats:styled-content> also markedly alleviated the effects of MSU<\/jats:styled-content>, such as by increasing cell viability and decreasing ICAM<\/jats:styled-content>\u20101 levels.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Drinking natural soda water may have a significant role in preventing gouty inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13181","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T09:07:24Z","timestamp":1509354444000},"page":"330-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u2018Shi Han Quan\u2019 natural soda water prevents development 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