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Genotyping for five <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the <jats:italic>ATG16L1<\/jats:italic> gene (rs4663421, rs2241880, rs4663396, rs6758317 and rs6431655) was performed using the improved multiplex ligase detection reaction (<jats:styled-content style=\"fixed-case\">iMLDR<\/jats:styled-content>) method. Haplotypes were built after linkage disequilibrium (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>) analysis. All analyses were stratified by gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences in the genotype frequencies at rs4663421 were found between female <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients and female controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.033). The frequencies of allele G of rs4663421 and allele C of rs6758317 were lower in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients than controls (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]\u00a0=\u00a00.391, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.175\u20130.876, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.019; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.499, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.263\u20130.949, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032, respectively) in females. However, no association remained significant after Bonferroni correction. rs4663396 and rs6758317 have been tested in high <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>, and were used to construct three haplotypes: ht1 (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>), ht2 (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) and ht3 (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>). The frequency of ht2 (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) haplotype was higher in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients than controls (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.003, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.053\u20133.808, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032) in females; similarly, no association existed after Bonferroni correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (rs4663421 and rs6758317) and the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> haplotype of the <jats:italic>ATG16L1<\/jats:italic> gene are possibly associated with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> susceptibility in a Chinese Han female population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13183","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T03:26:56Z","timestamp":1506482816000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single nucleotide polymorphisms of autophagy\u2010related 16\u2010like 1 gene are associated with ankylosing spondylitis in females: a case\u2013control study"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaona","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengya","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei Anhui 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