{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:33:21Z","timestamp":1778855601492,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Periostin has been shown to be involved in bone anabolism through the regulation of Wnt\u2010\u03b2\u2010catenin signaling. It may be one of the pathogenic mechanisms in syndesmophyte formation in ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>). The aim of this study was to evaluate serum periostin levels in patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and to assess relationships among biomarkers of bone formation and periostin in disease outcomes, particularly radiographic changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010seven consecutive <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients (78% male) and 48 healthy controls (75% male) were included in the study. Serum periostin, dickkopf\u20101 (<jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\u20101), sclerostin and vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) levels were measured using commercially available enzyme\u2010linked immunosorbent assay kits. Disease\u2010related characteristics of patients were assessed using Ankylosing spondylitis disease activity score \u2013 C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">ASDAS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), Bath <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> Disease Activity Index, Bath <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> Functional Index and Bath <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> metrology index. Radiographs were scored using the modified New York criteria and modified Stokes <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> spinal score (<jats:styled-content style=\"fixed-case\">mSASSS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with control subjects, patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> had significantly lower serum levels of periostin (<jats:italic>P<\/jats:italic> &lt; 0.001) and sclerostin (<jats:italic>P<\/jats:italic> &lt; 0.001), but higher serum levels of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001) and high\u2010sensitivity <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001). Serum periostin (<jats:italic>P<\/jats:italic> = 0.005) and sclerostin levels (<jats:italic>P<\/jats:italic> = 0.016) were significantly lower in patients with very high disease activity according to <jats:styled-content style=\"fixed-case\">ASDAS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. Current age (<jats:italic>P<\/jats:italic> = 0.009), age at symptom onset (<jats:italic>P<\/jats:italic> = 0.021) and hip joint involvement (<jats:italic>P<\/jats:italic> = 0.012) were independently associated with the development of syndesmophyte, in contrast to biomarkers of bone metabolism that we evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that periostin is down\u2010regulated in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients with highly active disease and may contribute to disease pathogenesis through an interaction with Wnt signaling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13186","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T05:22:36Z","timestamp":1505971356000},"page":"502-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of periostin and factors 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