{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:55:56Z","timestamp":1759938956126,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Reduced capillary density is considered the hallmark of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) leads to tissue hypoxia, a condition that usually induces angiogenesis. The objective of our study is to investigate mediators regulating angiogenesis in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and to correlate their levels with serological and clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>vascular endothelial growth factor, fibroblast growth factor\u20102, endostatin, thrombospondin\u20101 and soluble vascular cell and intracellular adhesion molecules (<jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\u20101) were measured in sera of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and normal subjects by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the pro\u2010 and anti\u2010angiogenic mediators, endostatin was significantly higher in SSc than in the control subjects. Out of the proteases involved in endostatin production, elastase but not cathepsin\u2010L, was significantly increased in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. The soluble adhesion molecules <jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\u20101 were significantly increased and they occur in parallel. <jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\u20101, but not <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\u20101 positively correlates with the inflammatory markers C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and erythrocyte sedimentation rate (ESR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endostatin, elastase and the soluble adhesion molecules (<jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\u20101) are potentially involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Moreover, the significant correlation observed between <jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> indicates that <jats:styled-content style=\"fixed-case\">sICAM<\/jats:styled-content>\u20101 might be a useful biomarker of the inflammatory state of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13196","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T05:52:39Z","timestamp":1507701159000},"page":"261-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Potential biomarkers in patients with systemic sclerosis"],"prefix":"10.1111","volume":"21","author":[{"given":"Andrea","family":"Delle Sedie","sequence":"first","affiliation":[{"name":"Rheumatology Unit Department of Clinical and 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