{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:27:16Z","timestamp":1788794836740,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK81872"],"award-info":[{"award-number":["R01 DK81872"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The goal of this study is to investigate how urinary angiostatin, vascular cell adhesion molecule 1 (<jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101) and established measures of renal function relate to specific histologic findings in paired kidney biopsy samples from patients with lupus nephritis (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Urine samples were collected from 54 <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> patients together with paired kidney biopsy samples and examined for urinary angiostatin and <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101 protein levels. Nonparametric tests were used to examine the association of both urinary biomarkers and established traditional laboratory markers of renal function with nine specific renal histologic features seen in <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>, including glomerular leukocyte infiltration, endocapillary proliferation, cellular crescents, fibrinoid necrosis, wire loops, interstitial inflammation, glomerulosclerosis, fibrous crescents, tubular atrophy and interstitial fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to traditional renal disease metrics, both urinary angiostatin and <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101 exhibited outstanding potential (area under the curve 0.97, 0.98, respectively) to predict renal biopsy activity index score \u2265\u00a07, which is associated with poor long\u2010term prognosis. Whereas urine <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101 was most significantly associated with fibrous crescents, urine angiostatin was most significantly associated with endocapillary proliferation, cellular crescents, fibrinoid necrosis and fibrous crescents in concurrent renal biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urinary angiostatin and <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101 are predictive of specific histological changes in concurrent <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> renal biopsies. Both urinary biomarkers are good candidates for use as noninvasive measures of renal pathology activity changes in <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13197","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T02:12:43Z","timestamp":1509070363000},"page":"1714-1727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Urine angiostatin and <scp>VCAM<\/scp>\u20101 surpass conventional metrics in predicting elevated renal pathology activity indices in lupus nephritis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-2158","authenticated-orcid":false,"given":"Samar","family":"Soliman","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering UT Southwestern Medical Center Dallas Texas USA"},{"name":"Rheumatology and Rehabilitation Department 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