{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:57:10Z","timestamp":1760101030293,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T00:00:00Z","timestamp":1512432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to study whether oral glucosamine hydrochloride (GlcN.<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l) or mucopolysaccharide protein (MucoP) has a structure\u2010modifying effect on an anterior cruciate ligament transection (<jats:styled-content style=\"fixed-case\">ACLT<\/jats:styled-content>) rabbit model of osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> was surgically induced in the right knees of rabbits by transection of the <jats:styled-content style=\"fixed-case\">ACLT<\/jats:styled-content>. The left knees served as a sham\u2010operated control. The animals were divided into four groups (<jats:italic>n<\/jats:italic> = 6 each): negative control (phosphate buffered saline, orally), positive control (oral celecoxib 10 mg\/kg body weight\/day), GlcN.<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l (oral 100 mg\/kg\/day) and MucoP (oral 100 mg\/kg\/day). Experimental animals were sacrificed after 8 weeks of treatment and the distal femur was removed for macroscopic examination, histological assessment, and terminal deoxynucleotidyl transferase\u2010mediated nick\u2010end labeling (<jats:styled-content style=\"fixed-case\">TUNEL<\/jats:styled-content>) assay of the <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On gross morphology, severe lesions were observed in articular cartilage in the negative control group. In the GlcN.<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l and MucoP treatment groups, fibrillations and cartilaginous lesions were significantly (<jats:italic>P<\/jats:italic> &lt; 0.05) decreased compared to the negative control group. In particular, degenerative changes in cartilage and chondrocyte cellularity were significantly reduced (<jats:italic>P<\/jats:italic> &lt; 0.05) in the positive control (celecoxib) group, GlcN.<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l treatment group and MucoP treatment group compared with the negative control group. <jats:styled-content style=\"fixed-case\">TUNEL<\/jats:styled-content> assay showed that apoptotic chondrocytes were significantly suppressed in the celecoxib group. Similar significant (<jats:italic>P<\/jats:italic> &lt; 0.05) results were seen in the GlcN.<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l group and MucoP group but apoptosis of chondrocytes were high in the negative control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that the protective effects of GlcN.<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l and MucoP may play a useful role in the clinical treatment of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13239","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T12:01:33Z","timestamp":1512475293000},"page":"620-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of oral glucosamine hydrochloride and mucopolysaccharide protein in a rabbit model of osteoarthritis"],"prefix":"10.1111","volume":"21","author":[{"given":"Da\u2010Hee","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Pathology Kyungpook National University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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