{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:15:38Z","timestamp":1776788138244,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["2014\u20102020.4.01.15\u20100012"],"award-info":[{"award-number":["2014\u20102020.4.01.15\u20100012"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007821","name":"Tartu \u00dclikool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Arterial pathology has been suggested to be involved in osteoarthritis (OA). Metabolic profiling enables the determination of low\u2010molecular\u2010weight molecules, which might further explain the pathogenesis of OA and its relationship with cardiovascular diseases (CVD). The aim of this study was to compare the metabolic profile of lipid metabolism\u2010related compounds and arterial stiffness in OA patients and in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The serum of 70 end\u2010stage OA patients prior to joint replacement surgery and 82 age\u2010matched controls were analyzed by the AbsoluteIDQ\u2122 p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria) using the targeted metabolomic approach. Arterial stiffness was assessed by measuring carotid\u2010femoral and carotid\u2010radial pulse wave velocity. Aortic\u2010brachial pulse wave velocity ratio (PWV\u2010ratio) was used as the measure of arterial stiffness gradient. Principal component analysis was performed to analyze the large number of metabolites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The OA patients had decreased levels of C10:1, C10:2, C12, C12:1, C14, C14:2, C14:1\u2010OH, carnitine palmitoyltransferase 1 (CPT1) ratio and total AC\/C0 compared with age\u2010matched controls. There was independent association between acylcarnitines and PWV\u2010ratio in the OA patients. Furthermore, acylcarnitines were associated with OA radiographic severity. The component that resembles acylcarnitines was an independent predictor of the PWV\u2010ratio for OA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found decreased levels of acylcarnitines in OA patients. Furthermore, medium\u2010and long\u2010chain acylcarnitines associated independently with arterial stiffness and were related to radiographic severity of OA. Thus, acylcarnities might play an important role in the association between OA and CVD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13251","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T21:29:19Z","timestamp":1515533359000},"page":"1211-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Medium\u2010 and long\u2010chain acylcarnitines are associated with osteoarthritis severity and arterial stiffness in end\u2010stage osteoarthritis patients: a case\u2010control study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-9031","authenticated-orcid":false,"given":"Kaspar","family":"Tootsi","sequence":"first","affiliation":[{"name":"Department of Traumatology and Orthopaedics University of Tartu Tartu Estonia"},{"name":"Endothelial Centre University of Tartu Tartu Estonia"},{"name":"Institute of Biomedicine and Translational Medicine 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