{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:13:09Z","timestamp":1780524789817,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It is generally accepted that hyperuricemia is commonly associated with psoriatic arthritis (PsA). However, variations in ethnicity, diet and habitat may contribute to differences in prevalence and risk factors for hyperuricemia in PsA patients. Moreover, Asian specific data is deficient. The primary objective of the present study was to determine the prevalence of hyperuricemia among PsA patients. The secondary objective was to explore its associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multi\u2010center, cross\u2010sectional observational study of 160 PsA patients from local Rheumatology clinics. Serum uric acid (<jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content>) level and other clinical parameters were measured and hyperuricemia was defined as <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> level greater or equal to 360 umol\/L in females and 420 umol\/L in males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine of 160 patients (30.6%) had hyperuricemia, of which 32 were men, 17 were women. Among those with hyperuricemia, mean <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> level was 500.7 \u00b1 95.9 umol\/L and 427.8 \u00b1 83.1 umol\/L in males and females, respectively. Univariate analysis found: (i) overweight status; (ii) obesity; (iii) Psoriasis Area and Severity Index; (iv) body surface area; (v) severe skin involvement, as being potentially associated with hyperuricemia. Regression model identified overweight status increased the likelihood of hyperuricemia in PsA, with an odds ratio of 4.4 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.0\u20139.5). Furthermore, there was moderately positive correlation (<jats:italic>r<\/jats:italic> = 0.37) between body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">SUA<\/jats:styled-content> level. No associations were found between arthritis conditions and duration, lipid profile, creatinine clearance; and hyperuricemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant proportion of PsA patients had asymptomatic hyperuricemia. It was closely related with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, which represented metabolic dysregulation; but not with severity of skin disease, joint involvement or renal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13265","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T03:57:18Z","timestamp":1516334238000},"page":"843-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hyperuricemia in Asian psoriatic arthritis patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-3758","authenticated-orcid":false,"given":"Tin Lok","family":"Lai","sequence":"first","affiliation":[{"name":"Rheumatology Team Department of Medicine Tseung Kwan O Hospital Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk Wan","family":"Yim","sequence":"additional","affiliation":[{"name":"Rheumatology Team Department of Medicine Tseung Kwan O Hospital Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui Yan","family":"Wong","sequence":"additional","affiliation":[{"name":"Rheumatology Team Department of Medicine Tseung Kwan O Hospital Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Chi","family":"Leung","sequence":"additional","affiliation":[{"name":"Rheumatology Team Department of Medicine and Geriatrics United Christian Hospital Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Leung","family":"Ng","sequence":"additional","affiliation":[{"name":"Rheumatology Team Department of Medicine and Geriatrics United Christian Hospital Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"62","article-title":"Psoriatic arthritis in Hong Kong","volume":"15","author":"Leung YY","year":"2007","journal-title":"Hong Kong J Dermatol Venereol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009740902978085"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.91"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12163"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.790801"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124743-200002000-00001"},{"issue":"4","key":"e_1_2_9_10_1","first-page":"12","article-title":"Hyperuricemia in Nigerian psoriatic patients","volume":"3","author":"Ukonu BA","year":"2016","journal-title":"J Med Den Sci Res"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0653-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03988.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13968"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e318259aa2e"},{"key":"e_1_2_9_16_1","first-page":"1","article-title":"Physical status: the use and interpretation of anthropometry. 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