{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:51:05Z","timestamp":1793652665069,"version":"4.5.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the prevalence of the anti\u2010melanoma differentiation\u2010associated gene 5 antibody (anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 Ab) in Hong Kong Chinese patients with dermatomyositis (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) and polymyositis (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>); in addition, to examine the association of anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 Ab and the clinical characteristics of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty consecutive existing patients with <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> being followed up at the Rheumatology Clinic of Kwong Wah Hospital, Hong Kong were recruited. Twenty patients with <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> were recruited from the same clinic as the controls. A commercial line blot immunoassay was used to detect the anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 Ab in all the participants. The frequencies of anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\u20105 Ab in the two groups were compared. The clinical characteristics of the patients with and without the antibody were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 Ab was found in 30% of patients with <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> but not in patients with <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>. All patients with the antibody exhibited the clinically amyopathic <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CADM<\/jats:styled-content>) phenotype. These patients were predominantly male, younger and with shorter disease duration. Anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 Ab was significantly associated with rapidly progressive interstitial lung disease (<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>) and digital ulcers. No statistically significant association was found between other disease or treatment variables and the antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 Ab is found exclusively in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients of the <jats:styled-content style=\"fixed-case\">CADM<\/jats:styled-content> subtype and is associated with <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> and digital ulcers, suggesting that examination of this antibody is clinically useful in Hong Kong Chinese patients with idiopathic inflammatory myopathies. However, further studies are required to assess its prognostic significance, and to explore the difference of its presentations in various populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13268","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T05:12:38Z","timestamp":1517289158000},"page":"1076-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of anti\u2010melanoma differentiation\u2010associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-9390","authenticated-orcid":false,"given":"Ho","family":"SO","sequence":"first","affiliation":[{"name":"Department of Medicine and Geriatrics Kwong Wah Hospital Kowloon Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky W.\u2010K.","family":"IP","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor T.\u2010L.","family":"WONG","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics Kwong Wah Hospital Kowloon Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.\u2010L.","family":"YIP","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics Kwong Wah Hospital Kowloon Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.323"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12451"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21728"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.896494"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"e_1_2_7_9_1","first-page":"S715","article-title":"Clinical phenotypes of Caucasian adult and juvenile dermatomyositis patients with anti\u2010MDA5 autoantibodies","volume":"64","author":"Betteridge Z","year":"2012","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22728"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181ca14ff"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2935-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01262.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/290797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker518"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.52"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21985"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker408"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq281"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.02.017"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:13:44Z","timestamp":1695510824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,30]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/1756-185X.13268"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13268","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,30]]},"assertion":[{"value":"2018-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}