{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:10:36Z","timestamp":1765177836368,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of tumor necrosis factor \u03b1 inhibitors (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i) on spinal radiographic progression in patients with ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were selected from patients at a single tertiary hospital between 1995 and 2014. Patients who used <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i with baseline and paired follow\u2010up radiographic data with a minimum interval of 2\u00a0years were included. Time to start <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i was defined as the time from symptom onset to the start of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i use. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i index was defined as the ratio of the period of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i use to the entire period of disease. Radiographic damage was assessed by the modified Stoke Ankylosing Spondylitis Spine Score (<jats:styled-content style=\"fixed-case\">mSASSS<\/jats:styled-content>). Univariable and multivariable linear regression analyses were used to identify factors associated with radiographic progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 151 patients were included in the analysis. Seventeen (11.3%) patients were female and mean \u0394m<jats:styled-content style=\"fixed-case\">SASSS<\/jats:styled-content>\/year was 1.01 units\/year. Mean X\u2010ray follow\u2010up duration was 102.9\u00a0\u00b1\u00a054.9\u00a0months. Mean time from symptom onset to start of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i use was 104.8\u00a0\u00b1\u00a083.6\u00a0months (median 84\u00a0months) and mean <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i index was 42.9\u00a0\u00b1\u00a023.8% (median 40.9%). In multivariable analysis, initial <jats:styled-content style=\"fixed-case\">mSASSS<\/jats:styled-content>, initial C\u2010reactive protein, body mass index, current smoker, and delayed start of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i use were associated with radiographic progression. Presence of peripheral arthritis and the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i index were negatively associated with radiographic progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A delay in starting <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i use and low <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i index were associated with radiographic progression. Early and long\u2010term use of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i appear to reduce spinal radiographic progression in patients with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13270","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T06:27:49Z","timestamp":1522736869000},"page":"1098-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of tumor necrosis factor \u03b1 inhibitors on spinal radiographic progression in patients with ankylosing spondylitis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6227-681X","authenticated-orcid":false,"given":"Hyemin","family":"Jeong","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Soonchunhyang University Hospital Bucheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Hee","family":"Eun","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine Jeju National University Hospital Jeju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaejoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Hong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Soonchunhyang University Hospital Bucheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Mi","family":"Koh","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon\u2010Suk","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1136\/annrheumdis-2011-201252"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1136\/annrheumdis-2012-201370"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1002\/art.21054"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1136\/annrheumdis-2015-207897"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1002\/art.11104"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1136\/ard.2004.035105"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1002\/art.21913"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1002\/art.23471"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1186\/ar2794"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1136\/ard.2004.033472"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1093\/rheumatology\/kem166"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1136\/annrheumdis-2012-203075"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1038\/nm1538"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1038\/nrrheum.2009.258"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1136\/annrheumdis-2013-204485"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1136\/ard.2004.020503"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1002\/art.38070"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1002\/art.1780270401"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1136\/ard.2010.133488"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1016\/j.jbspin.2015.06.013"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.3899\/jrheum.080871"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1016\/j.jbspin.2015.09.006"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1136\/annrheumdis-2012-202698"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.1186\/ar2496"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1002\/art.24132"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_1","DOI":"10.1136\/annrheumdis-2011-200208"},{"doi-asserted-by":"publisher","key":"e_1_2_6_28_1","DOI":"10.1136\/annrheumdis-2013-203643"},{"doi-asserted-by":"publisher","key":"e_1_2_6_29_1","DOI":"10.1002\/art.21790"},{"doi-asserted-by":"publisher","key":"e_1_2_6_30_1","DOI":"10.1136\/annrheumdis-2014-205178"},{"doi-asserted-by":"publisher","key":"e_1_2_6_31_1","DOI":"10.1136\/annrheumdis-2011-200859"},{"doi-asserted-by":"publisher","key":"e_1_2_6_32_1","DOI":"10.1002\/art.33465"},{"doi-asserted-by":"publisher","key":"e_1_2_6_33_1","DOI":"10.1371\/journal.pone.0122693"},{"doi-asserted-by":"publisher","key":"e_1_2_6_34_1","DOI":"10.1007\/s00296-004-0451-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_35_1","DOI":"10.1002\/art.24585"},{"doi-asserted-by":"publisher","key":"e_1_2_6_36_1","DOI":"10.1136\/annrheumdis-2013-205133"},{"doi-asserted-by":"publisher","key":"e_1_2_6_37_1","DOI":"10.1186\/ar3841"},{"doi-asserted-by":"publisher","key":"e_1_2_6_38_1","DOI":"10.2165\/11318100-000000000-00000"},{"doi-asserted-by":"publisher","key":"e_1_2_6_39_1","DOI":"10.1080\/03009740600991760"},{"doi-asserted-by":"publisher","key":"e_1_2_6_40_1","DOI":"10.1007\/s10067-012-1999-z"},{"doi-asserted-by":"publisher","key":"e_1_2_6_41_1","DOI":"10.3899\/jrheum.120595"},{"doi-asserted-by":"publisher","key":"e_1_2_6_42_1","DOI":"10.1093\/rheumatology\/keu014"},{"doi-asserted-by":"publisher","key":"e_1_2_6_43_1","DOI":"10.1093\/rheumatology\/keh373"},{"doi-asserted-by":"publisher","key":"e_1_2_6_44_1","DOI":"10.3899\/jrheum.100094"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:12:55Z","timestamp":1695510775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,2]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/1756-185X.13270"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13270","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2018,4,2]]},"assertion":[{"value":"2018-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}