{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:26:53Z","timestamp":1781094413063,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Unidad de Investigaci\u00f3n del Colegio Mexicano de Reumatolog\u00eda"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the stiffness of parotid and submandibular glands using elastography ultrasound and to correlate it with B\u2010mode ultrasonographical, clinical and serological features, salivary profibrotic and inflammatory chemokines, and salivary gland fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed B\u2010mode and elastography ultrasound of major salivary glands of 26 patients with primary Sj\u00f6gren's syndrome. We registered the shear wave velocity (SWV) and correlated it with the morphologic ultrasonographic changes assessed by the Hocevar scale. We assessed the European League Against Rheumatism (EULAR) Sj\u00f6gren's Syndrome Disease Activity Index (ESSDAI), EULAR Sj\u00f6gren's Syndrome Patient Reported Index (ESSPRI), non\u2010stimulated whole salivary flow rate (NSWSF), C3 and C4 levels, anti\u2010Ro\/La antibodies, salivary inflammatory (C\u2010X\u2010C motif ligand 13 [CXCL13], CXCL10, CXCL8, C\u2010C motif ligand 2 [CCL2], interleukin 10 [IL\u201010] and IL\u20106) and pro\u2010fibrotic (CXCL14, CCL28, tumor necrosis factor\u2010related apoptosis\u2010inducing ligand and transforming growth factor \u03b2) chemokines and cytokines and evaluated the presence of fibrosis in the minor salivary gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two percent of patients were women; mean age was 51.1\u00a0\u00b1\u00a011\u00a0years; median disease duration was 6.1\u00a0years; 92.3% had oral symptoms and 26.9% fibrosis. The median B\u2010mode score was 22.2 points and the median SWV 2.5\u00a0m\/s (\u03c4\u00a0=\u00a00.53, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The SWV correlated with the NSWSF (\u03c4\u00a0=\u00a0\u20130.53, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001), ESSDAI (\u03c4\u00a0=\u00a00.31, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03), glandular ESDDAI domain (\u03c4\u00a0=\u00a00.36, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), C4 levels (\u03c4\u00a0=\u00a0\u20130.32, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04), salivary CXCL13 (\u03c4\u00a0=\u00a00.29, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03) and CXCL10 (\u03c4\u00a0=\u00a00.30, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003), but not with age and fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WV correlated with the B\u2010mode ultrasound score, systemic and glandular activity and in a large degree with CXCL10, an inflammatory chemokine, but not with fibrosis. An increased SWV might represent chronic glandular inflammation rather than fibrotic changes in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13292","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T21:54:09Z","timestamp":1523051649000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Elastographic ultrasound: an additional image tool in Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"Eric","family":"Kimura\u2010Hayama","sequence":"first","affiliation":[{"name":"Department of Radiology Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Criales\u2010Vera","sequence":"additional","affiliation":[{"name":"Department of Radiology Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez Mexico City 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