{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:06:19Z","timestamp":1778259979851,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K19162"],"award-info":[{"award-number":["15K19162"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K08963"],"award-info":[{"award-number":["17K08963"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H23\u2010meneki\u2010shitei\u2010016"],"award-info":[{"award-number":["H23\u2010meneki\u2010shitei\u2010016"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H26\u2010meneki\u2010shitei\u2010021"],"award-info":[{"award-number":["H26\u2010meneki\u2010shitei\u2010021"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>It is controversial whether the use of biological disease\u2010modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non\u2010TNFI users with rheumatoid arthritis (RA) over 3 years in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using the Japanese health insurance database, we assigned patients with at least one RA diagnostic code and one prescription for any DMARDs (RA cases) recorded between January 2005 and December 2013 to the RA group. We randomly selected five age\u2010, sex\u2010, calendar year\u2010 and observation length\u2010matched non\u2010RA cases for each RA case (non\u2010RA group), and assessed associations between RA and HZ. To evaluate the risks of HZ in TNFI and non\u2010TNFI users, we conducted a nested case\u2010control study (NCC) in the RA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The RA group (<jats:italic>n<\/jats:italic> = 6712) had a significantly higher crude incidence rate of HZ than the non\u2010RA group (<jats:italic>n<\/jats:italic> = 33 560) (14.2 <jats:italic>vs<\/jats:italic>. 8.3\/1000 patient\u2010years), and the adjusted odds ratio (95% confidence interval) of the RA versus non\u2010RA groups was 1.43 (1.17\u20131.75). The NCC demonstrated that use of TNFI, non\u2010TNFI, methotrexate, or immunosuppressive DMARDs did not increase the risks of HZ. Use of corticosteroid \u2265 5 mg\/day conveyed a significant risk of HZ in patients with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rheumatoid arthritis was significantly associated with the development of HZ, and use of corticosteroids \u2265 5 mg\/day was identified as a significant risk factor, whereas either TNFI or non\u2010TNFI use were not.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13300","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T06:14:52Z","timestamp":1524032092000},"page":"1670-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["No increased risk of herpes zoster in TNF inhibitor and non\u2010TNF inhibitor users with rheumatoid arthritis: epidemiological study using the Japanese health insurance database"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1640-1373","authenticated-orcid":false,"given":"Ryoko","family":"Sakai","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases Institute of Rheumatology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-5660","authenticated-orcid":false,"given":"Shoko","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Rheumatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Rheumatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayoko","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases Institute of Rheumatology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Rheumatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waka","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Rheumatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michi","family":"Tsutsumino","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases Institute of Rheumatology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Rheumatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Rheumatology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases Institute of Rheumatology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6418-2603","authenticated-orcid":false,"given":"Masayoshi","family":"Harigai","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases Institute of Rheumatology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00044-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(03)00125-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1053-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2911"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.06.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21928"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6347-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.101137"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.03.018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21812"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.07.009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22628"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1099"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.984829"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014032"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161196"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38745"},{"issue":"10","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","DOI":"10.1002\/art.38745","article-title":"Herpes zoster in patients with moderate to severe rheumatoid arthritis treated with baricitinib","volume":"68","author":"Winthrop KL","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21599"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20110035"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1106682"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr206"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0305"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00297-2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140210"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210708"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201108"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.146"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12679"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0406-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0541-5"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1123211"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130466"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/598331"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22470"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1756-185X.13300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.13300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T20:40:55Z","timestamp":1694896855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.13300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/1756-185X.13300"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.13300","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}