{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:58:12Z","timestamp":1740149892899,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009980","name":"Medizinische Universit\u00e4t Innsbruck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess demographical and clinical data in a Middle\u2010European cohort of patients with Adamantiades\u2013Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content>), together with the use of medication in adherence to international guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study, in\u2010 and outpatients of an Austrian secondary and tertiary university hospital center were analyzed independent from the medical discipline involved. After ethics approval, screening for <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content>\u2010patients in the clinical information system resulted in 1821 documents from 1997 to 2016. Patients fulfilling the International Criteria for Beh\u00e7et's Disease were included, and <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> symptoms and signs together with medical interventions for immunosuppression, anticoagulation and pain management were identified by individual chart reviews and evaluated for conformity with international recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 76 <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> patients were identified with 39.1% Austrian and 37.0% Turkish origin. Genital aphthae and skin manifestations were more frequent, neurological, gastrointestinal and vascular manifestations less frequent in <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> patients of Turkish origin living in Austria compared to those living in Turkey (each <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The male\u2010to\u2010female ratio averaged 0.86 (0.39 in patients with Austrian and 1.43 with Turkish backgrounds), and was 3.3 in patients with venous manifestations. Out of 174 medical interventions, 55.2% fully matched the European League Against Rheumatism recommendations of 2008, and 93.7% were considered at least as equal to the recommendations. Indications for tumor necrosis factor inhibition were in line with the 2007 Sfikakis recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this Middle\u2010European <jats:styled-content style=\"fixed-case\">ABD<\/jats:styled-content> cohort clinical presentations between patients of Austrian and Turkish origin do not strongly vary, whereas Turkish patients from the non\u2010endemic Innsbruck cohort present differently compared to patients living in Turkey. The role of such cohort analyses will increase, from the epidemiological as well as the management perspective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.13306","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:46:35Z","timestamp":1523965595000},"page":"2151-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differential clinical presentation of Adamantiades\u2013Beh\u00e7et's disease in non\u2010endemic and endemic areas: retrospective data from a Middle\u2010European cohort study"],"prefix":"10.1111","volume":"21","author":[{"given":"Thomas","family":"Moosmann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Clinic II Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Veraar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic II Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinic I  Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"Fraedrich","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Frech","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Horninger","sequence":"additional","affiliation":[{"name":"Department of Urology Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"Ratzinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Streif","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinic I  Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Teuchner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Willeit","sequence":"additional","affiliation":[{"name":"Department of Neurology Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Zlamy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinic I  Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"De Zordo","sequence":"additional","affiliation":[{"name":"Department of Radiology Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-7809","authenticated-orcid":false,"given":"Michael","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic II Medizinische Universit\u00e4t Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0502-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.02.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000349"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-012-2601-4"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"S176","article-title":"Prevalence of Beh\u00e7et's disease in the province of Brescia in northern Italy","volume":"32","author":"Cartella S","year":"2014","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"28","article-title":"High prevalence of Beh\u00e7et's disease in southern Italy","volume":"31","author":"Olivieri I","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080432"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem034"},{"key":"e_1_2_9_11_1","unstructured":"European Medicines Agency.European public assessment reports. 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